Usage of Procalcitonin to Reduce Antibiotics Duration in VAP in Neurosurgical ICU

Procalcitonin as a Sepsis Biomarker in Guiding Antibiotics Treatment Duration in Ventilator Associated Pneumonia in Neuro-ICU: A Randomised Controlled Trial

Using Procalcitonin Tests to reduce antibiotics duration in Neurosurgical patients with Ventilated Associated Pneumonia

Patients who are more than 18 years old who are admitted to Neurosurgical ICU will be recruited 48hours after ventilation if matches criteria for ventilator associated pneumonia. Patients will be randomised into 2 groups. first group will be procalcitonin guided in addition to conventionally guided sepsis assessment (TWC, CRP, body temperature). second group is only conventionally guided sepsis assessment. in procalcitonin guided group, blood sample will be taken on Day 1 of recruitment and day 5. On day 5 , the procalcitonin level will be compared to recommendations in PRORATA trial. If procalcitonin level is below the level to withhold antibiotics, recommendation will be made to the primary physician to off the antibiotics. Another Procalcitonin level will be repeated on Day 7 to rule out reinfection. This study aims to compare the duration of antibiotics and length of ICU stay among the 2 groups.

This study will fill up the gap among the lack of datas in neurosurgical patients.

Inclusion Criteria:

• Patients admitted to Neuro-ICU & Trauma ICU
• Patients aged >18 years old.
• Ventilation for >48 hours
• VAP and treated with antibiotics <24hours prior to inclusion in trial.
• Patient with arterial line or central line

Exclusion Criteria:

• Patients who are on antibiotics but not assumed or proven to have VAP
• Expected short ICU stay (<3 Days)
• Non-bacterial infections
• Long term antibiotic treatment (transplant or chemotherapy patients, endocarditis, osteomyelitis)
• Hospitalisation 48hours before enrolment
• Severe immunosuppression
• Pregnancy
• Primary team's decision to continue antibiotics for 14 days prior to trial
• DNAR or expected to die within 5 days