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A single-center, prospective cohort trial aims to provide stronger evidence regarding the impact of degenerative spondylolisthesis on the clinical outcome of unilateral biportal endoscopy for lumbar spinal stenosis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DS Group | Patients with degenerative spondylolisthesis Meyerding grade Ⅰ (slippage >3 mm but <25%) will be identified as having lumbar spinal stenosis combined with degenerative spondylolisthesis and will be allocated to the DS group. | ||
| Non-DS Group | Patients not with degenerative spondylolisthesis will be identified as having lumbar spinal stenosis only and will be allocated to the Non-DS group. |
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| Measure | Description | Time Frame |
|---|---|---|
| Oswestry Disability Index (ODI) | 0-100%, the higher the score, the more severe the lumbar spine dysfunction | From enrollment to the end of follow-up at 2 year |
| Measure | Description | Time Frame |
|---|---|---|
| X-ray | Progression of lumbar spondylolisthesis, assessed by postoperative lumbar radiography; (2) Measurement of sagittal translation, segmental angulation, and posterior opening based on postoperative standing flexion-extension radiographs | From enrollment to the end of follow-up at 2 year |
| Computed tomography (CT) scan |
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Inclusion Criteria:
Exclusion Criteria:
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Eligible patients with LSS who are scheduled to undergo UBE-based decompression, performed by an experienced spine surgeon at Beijing Friendship Hospital, will be recruited from the outpatient clinic for this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiang Li | Contact | +86 10 6313 9155 | muzixiangxin2022@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Friendship Hospital | Recruiting | Beijing | Beijing Municipality | 100050 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41034885 | Derived | Liu Y, Li G, Yu L, Sun H, Zhu B, Fei Q, Lo Y, Yang Y, Tan H, Li X. Degenerative spondylolisthesis and unilateral biportal endoscopic decompression for lumbar spinal stenosis: a single-center, prospective cohort trial protocol. BMC Musculoskelet Disord. 2025 Oct 1;26(1):900. doi: 10.1186/s12891-025-09179-6. |
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Assessment of bone resection area and preservation rate of the facet joint using postoperative computed tomography (CT) scans |
| From enrollment to the end of follow-up at 2 year |
| Magnetic resonance imaging (MRI) | Calculation of the enlargement ratio of the dural sac based on postoperative magnetic resonance imaging (MRI) | From enrollment to the end of follow-up at 2 year |
| Surgical complication | Any adverse events will be recorded to evaluate the safety of decompression using UBE for LSS with or without DS | From enrollment to the end of follow-up at 2 year |
| Visual analog scale (VAS) score for lower back pain | 0-10, the higher the score, the more severe the pain | From enrollment to the end of follow-up at 2 year |
| Visual analog scale (VAS) score for leg pain | 0-10, the higher the score, the more severe the pain | From enrollment to the end of follow-up at 2 year |
| Operative time | Time to perform the operation | Immediately after the surgery |
| Intraoperative blood loss | B、 Blood loss during the surgery | Immediately after the surgery |
| Postoperative hospital stays | Number of days in hospital after operation | Immediately after the discharge |
| Japanese Orthopaedic Association (JOA) score | 0-29, the higher the score, the better the lumbar spine function | From enrollment to the end of follow-up at 2 year |
| Modified MacNab criteria | According to satisfaction, it is divided into four levels: excellent, good, acceptable, and poorexcellent, good, fair, and poor | From enrollment to the end of follow-up at 2 year |
| Improvement ratio of Visual analog scale (VAS) score for lower back pain | Improvement ratio= (preoperative VAS-postoperative VAS/preoperative VAS, ranging from 0-100%, the higher the score, the better the improment of symptoms | From enrollment to the end of follow-up at 2 year |
| Improvement ratio of Visual analog scale (VAS) score for leg pain | Improvement ratio= (preoperative VAS-postoperative VAS/preoperative VAS, ranging from 0-100%, the higher the score, the better the improment of symptoms | From enrollment to the end of follow-up at 2 year |
| Improvement ratio of Japanese Orthopaedic Association (JOA) score | Improvement ratio= (postoperative JOA-preoperative JOA/preoperative VAS, ranging from 0-100%, the higher the score, the better the improment of spinal function | From enrollment to the end of follow-up at 2 year |
| Improvement ratio of Oswestry Disability Index (ODI) | Improvement ratio= (preoperative ODI-postoperative ODI)/preoperative ODI, ranging from 0-100%, the higher the score, the better the improment of symptoms | From enrollment to the end of follow-up at 2 year |
| White blood cell count | White blood cell count of venous blood | From enrollment to 3 days after surgery |
| Percentage of neutrophils (N%) | The proportion of neutrophils relative to the total white blood cell count | From enrollment to 3 days after surgery |
| C-reactive protein level | The level of C-reactive protein in blood | From enrollment to 3 days after surgery |
| Creatine kinase level | The level of creatine kinase in blood | From enrollment to 3 days after surgery |
| Lactate dehydrogenase level | The level of Lactate dehydrogenase in blood | From enrollment to 3 days after surgery |
| Myoglobin level | The level of myoglobin in blood | From enrollment to 3 days after surgery |
| ID | Term |
|---|---|
| D013130 | Spinal Stenosis |
| ID | Term |
|---|---|
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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