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This study aimed to compare the long-term efficacy and safety of levetiracetam and valproate in treatment of idiopathic generalized epilepsy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Levetiracetam | Patients with idiopathic generalized epilepsy who were under treatment with levetiracetam |
| |
| Sodium valproate | Patients with idiopathic generalized epilepsy who were under treatment with valproate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levetiracetam | Drug | Patients with idiopathic generalized epilepsy who were under treatment with levetiracetam |
|
| Measure | Description | Time Frame |
|---|---|---|
| Seizure free rate | The percent of patients who remained seizure free on treatment | 1 to 5 years |
| Time to first seizure | The interval between start of treatment and recurrence of seizure | 1 to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Retention rate | The percent of patients who remained on treatment with levetiracetam or valproate | 1 to 5 years |
| Time to withdrawal | The interval between start and withdrawal of treatment |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with idiopathic generalized epilepsy (juvenile myoclonic epilepsy or generalized tonic-clonic seizure alone) who are on monotherapy with levetiracetam or sodium valproate
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bu Ali Sina Hospital | Sari | Mazandaran | 4815837477 | Iran |
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| ID | Term |
|---|---|
| C562694 | Epilepsy, Idiopathic Generalized |
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| ID | Term |
|---|---|
| D000077287 | Levetiracetam |
| D014635 | Valproic Acid |
| ID | Term |
|---|---|
| D000081 | Acetamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000085 | Acetates |
| D000144 |
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| Sodium valproate | Drug | Patients with idiopathic generalized epilepsy who were under treatment with valproate |
|
| 1 to 5 years |
| Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D011760 | Pyrrolidinones |
| D011759 | Pyrrolidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D010421 | Pentanoic Acids |
| D014631 | Valerates |
| D005232 | Fatty Acids, Volatile |
| D005227 | Fatty Acids |
| D008055 | Lipids |