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In this study, investigators compared the systemic inflammatory responses after percutaneous nephrolithotomy (PCNL) patients who were given an expanded empirical antibiotic regimen based on the prediction of the possibility of bacteria identified by Gram staining the first urine after renal puncture and patients whose antibiotic regimen was not performed and whose antibiotic regimen was adjusted according to patient symptoms and culture results. Investigators aimed to test its diagnostic value in predicting and preventing complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gram staining | Experimental | Gram staining of post-puncture urine in percutaneous nephrolithotomy |
|
| control | No Intervention | non-intervention percutaneous nephrolithotomy |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gram staining of the first urine after intraoperative renal puncture to predict the systemic inflammatory response after percutaneous nephrolithotomy. | Diagnostic Test | Gram staining of the first urine after intraoperative renal puncture to predict the systemic inflammatory response after percutaneous nephrolithotomy. |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of Gram stain in predicting systemic inflammatory response after percutaneous nephrolithotomy. | Gram staining of urine after puncture to detect the presence of bacteria that are a possible source of infection according to the rate of gram-stained and non-gram-stained patients by microscopic examination. | immediately after the surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Change of antibiotic regimen after bacterial estimation of Gram stain | The percentage of patients whose antibiotic regimen was changed by estimating bacteria after Gram staining did not progress to systemic inflammatory response syndrome. Systemic inflammatory response criteria: temperature less than 36 °C or higher than 38 °C, heart rate more than 100 beats per minute, respiratory rate more than 20 per minute, leukocyte count greater than 12 × 10 up 9/L or 4 × 10 up 9/L less than L, systolic blood pressure falling below 90 mmHg, or diastolic blood pressure falling below 40 mmHg |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bedreddin Kalyenci | Contact | +905554859583 | bedreddin84@windowslive.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Adıyaman University, Medicine of Faculty | Recruiting | Adıyaman | 02400 | Turkey (Türkiye) |
Patient clinical data before and after surgery
starting 6 months after publication
Data will be shared with all researchers conducting research on the prevention and detection of infectious consequences after percutaneous nephrolithotomy.
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The patients included in the study were randomized by a block randomization method by an independent researcher, hidden from the patients and the responsible clinicians, using a computerized number tool.
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|
| immediately after the surgery |
| ID | Term |
|---|---|
| D005334 | Fever |
| D018746 | Systemic Inflammatory Response Syndrome |
| ID | Term |
|---|---|
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D012769 | Shock |
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