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this study tries to measure the effect of intradialytic ketoacid analogues on inflammatory parameters
this study will measure inflammation parameters:
the duration of intervention is 12 weeks
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | patient who undergo hemodialysis two times a week | |
| intervention | Experimental | will be given parenteral ketoacid analogues intradialytics two times a week |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketoacid | Drug | 250 ml ketoacid two hours before the hemodialysis session ended |
|
| Measure | Description | Time Frame |
|---|---|---|
| interleukin-6 | in pg/mL, no limit values | 12 weeks |
| malnutrition inflammation score | consists of ten components, based on subjective complaints combined with albumin serum (in g/dL), serum iron (in micromol/L, and total iron binding capacity (in micromol/L). the sum of all components >5 means have high inflammation status | 12 weeks |
| neutrophil lymphocyte ratio | the percentage ratio of neutrophil count and lymphocyte count will be combined to neutrophil lymphocyte ratio | 12 weeks |
| monocyte lymphocyte ratio | the percentage ratio of monocyte count and lymphocyte count will be combined to monocyte lymphocyte ratio | 12 weeks |
| thrombocyte lymphocyte ratio | the percentage ratio of thrombocyte (in per microliter of blood) and lymphocyte count will be combined to thrombocyte lymphocyte ratio | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| RSUP Fatmawati | Jakarta | Jakarta Selatan | 12430 | Indonesia |
the data is restricted only for investigators
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D007651 | Keto Acids |
| ID | Term |
|---|---|
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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intervention and control
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