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Sufentanil Target Controlled infusion (TCI, Gepts model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol TCI (Eleveld model) has not been investigate yet.
Authors aim to investigate its effect on Patient State index (PSi), the power spectrum EEG, the Analgesia Nociception Index (ANI) nad pupillometry values during maintenance durin TIVA-TCI with Propofol and Sufentanil.
Sufentanil Target Controlled infusion (TCI, Gepts model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol TCI (Eleveld model) has not been investigate yet.
Authors aim to investigate its effect on Patient State index (PSi), the power spectrum EEG, the Analgesia Nociception Index (ANI) and pupillometry values during maintenance during TIVA-TCI with Propofol and Sufentanil.
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| Measure | Description | Time Frame |
|---|---|---|
| Effects of Sufentanil on Patient State index (PSi) during stable Propofol general anesthesia | Evaluate if sufentanil variations during general anesthesia has an impact on the PSi values | PSi values and Sufentanil Target Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery |
| Effects of Sufentanil on Electroencephalogram (EEG) power spectrum during stable Propofol general anesthesia | Evaluate if sufentanil variations during general anesthesia has an impact on the EEG power spectrum | EEG power spectrum and Sufentanil Target Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery |
| Effects of Sufentanil on Analgesia Nociception Index (ANI) during stable Propofol general anesthesia | Evaluate if sufentanil variations during general anesthesia has an impact on the ANI values | ANI values and Sufentanil Target Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Analgesia Nociception Index (ANI) values and postoperative pain | Evaluate if different ANI values at the same Sufentanil concentrations has an impact on postoperative pain | Numeric Rating Scale (NRS) will be evaluated after the end of surgery and 24 hours after the end of surgery and compared to ANI values after 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Women undergoing brast cancer surgery with general anesthesia with Propofol and SufentanilTCI will be recruited
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| Name | Affiliation | Role |
|---|---|---|
| Federico Linassi, MD | University of Padova | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Treviso Regional Hospital | Treviso | TV | 31100 | Italy |
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| Patient State Index (PSi) values and postoperative delirium |
Evaluate if different PSi values at the same Sufentanil concentrations has an impact on postoperative pain |
| Confusion assessment method (CAM) test for delirium will be performed after the end of surgery and compared to PSi values after 24 hours |
| Analgesia Nociception Index (ANi) values and postoperative nausea and vomiting | Evaluate if different ANi values at the same Sufentanil concentrations has an impact on postoperative nausea and vomiting. | Nausea and vomiting occurrence will be detected hours atend of surgery and compared to ANI values after 24 hours |