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The idiopathic generalized epilepsies (IGEs) have historically included the syndromes childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic-clonic seizures alone (GTCA). Recognition of the IGEs is important for clinical care, as it informs diagnosis, prevents unnecessary investigation, allows optimal selection of anti-seizure medications (ASMs), and provides prognostic guidance.
According to the new ILAE definition in 2022, the study aims to describe the clinical features, electroencephalographic, imaging findings and long-term prognosis.
the Long-term prognosis include the rate of drug-resistent epilepsy, relapse after drug withdrawn, common comorbidities such as mood disorders, attention deficit hyperactivity disorder (ADHD) and learning disabilities.
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| Measure | Description | Time Frame |
|---|---|---|
| The proportion of drug-resistent epilepsy | We defined drug-resistant cases as those patients who have failed two or more trials of broad-spectrum ASMs or those otherwise indicated in IGE syndromes | through study completion, an average of 1 year |
| The proportion of seizure freedom | We defined seizure freedom according to the International League Against Epilepsy (ILAE) definition | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of psychiatric comorbidity | The psychiatric comorbidities mainly include anxiety and depression, which are evaluated by Hamilton anxiety scale and Hamilton depression scale, respectively. | through study completion, an average of 1 year |
| The proportion of psychosocial outcome |
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Inclusion Criteria:
Exclusion Criteria:
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Patients are consecutively and prospectively recruited from epilepsy center and clinics
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chunhong Shen | Contact | +86 0571 87783872 | shen_neurology@zju.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Chunhong Shen | Second Affiliated Hospital, School of Medicine, Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China | Recruiting | Hangzhou | Zhejiang | 310000 | China |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| C562694 | Epilepsy, Idiopathic Generalized |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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such as university entrance, marry |
| through study completion, an average of 1 year |
| The proportion of seizure relapse after antiseizure medication withdrawn | Antiseizure medication withdrawn should be recommended by epilepsy experts | through study completion, an average of 1 year |