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| Name | Class |
|---|---|
| Kent State University | OTHER |
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The goal of this clinical trial is to learn if the Positive Peers mobile app intervention increases rates of viral suppression in young (13-34 y/o) persons with HIV.
Does use of the Positive Peers app improve viral suppression among young minority persons with HIV? What user characteristics are associated with a) viral suppression, b) retention in care, and c) perceived HIV-related stigma?
Participants will:
Participants will load the Positive Peers app on their personal device (either immediately or after a 6 month delay) and be encouraged to use the app regularly. Eligible patients who decline participation in the intervention will be asked to participate in an observational arm.
All participants will complete a brief baseline survey. Participants in the immediate or delayed arms will also complete surveys at 3, 6, 9, and 12 months. Medical data will be collected from the medical record and usage data will be collected from the app itself. Medical data will be collected for 12 months prior to enrollment and 18 months after enrollment. At the end of the study, participants are welcome to continue to use the app.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Immediate Start | Experimental | Participants in the immediate start arm will download and begin use of the Positive Peers app at the enrollment visit. |
|
| Delayed Start | Active Comparator | Participants in the delayed start arm will download and begin use of the Positive Peers app 6 months after enrollment |
|
| Observational Cohort | No Intervention | Participants in the observational cohort have declined participation in the clinical trial but agree to do the baseline survey and have medical outcomes data recorded. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Positive Peers mobile app | Other | Positive Peers is a multifunctional mobile app using a mind, body, spirit theme aimed to improve HIV care outcomes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Viral suppression | Proportion of participants who have HIV viral load <200 copies/ ml | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Correlates of app use and viral suppression | Identify participant demographic and psychosocial factors from the baseline survey that correlate with app use and viral suppression (viral load < 200 copies/ ml). | 6 months |
| Correlates of app use and retention in care |
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Inclusion Criteria:
One of the following:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jennifer McMillen-Smith, LISW-S | Contact | 2167784051 | jmsmith@metrohealth.org | |
| Ann Avery, MD | Contact | aavery@metrohealth.org |
| Name | Affiliation | Role |
|---|---|---|
| Ann Avery, MD | MetroHealth/ CWRU | Principal Investigator |
| Mary Step, PhD | Kent State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northeast Valley Health Corporation | Recruiting | Van Nuys | California | 91405 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36170001 | Background | Step MM, McMillen Smith J, Lewis SA, Avery AK. Using the Positive Peers Mobile App to Improve Clinical Outcomes for Young People With HIV: Prospective Observational Cohort Comparison. JMIR Mhealth Uhealth. 2022 Sep 28;10(9):e37868. doi: 10.2196/37868. | |
| 33136057 | Background | Comulada WS, Step M, Fletcher JB, Tanner AE, Dowshen NL, Arayasirikul S, Keglovitz Baker K, Zuniga J, Swendeman D, Medich M, Kao UH, Northrup A, Nieto O, Brooks RA; Special Projects Of National Significance Social Media Initiative Study Group. Predictors of Internet Health Information-Seeking Behaviors Among Young Adults Living With HIV Across the United States: Longitudinal Observational Study. J Med Internet Res. 2020 Nov 2;22(11):e18309. doi: 10.2196/18309. |
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Participant survey data, backend usage data and medical record data will be deidentified and made available to researchers with a reasonable request and plan for use.
within 1 year after award ends
Request for data to reproduce results or for meta-analysis.
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| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
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randomized control trial with observational cohort for eligible patients who decline participation
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Identify participant demographic and psychosocial factors from the baseline survey that correlate with app use on retention in care (completing office visit at least every 6 months) |
| 12 months |
| Correlates of app use and HIV related perceived stigma | Identify participant demographic and psychosocial factors from the baseline survey that correlate with app use and changes in HIV-related perceived stigma on the HIV Stigma scale (Eriksson). | 3 months |
| Infectious Disease Practice- Rutgers University | Recruiting | Newark | New Jersey | 07103 | United States |
|
| Equitas Health | Recruiting | Cincinnati | Ohio | 45206 | United States |
|
| Equitas Health | Recruiting | Columbus | Ohio | 43203 | United States |
|
| Thomas Street Clinic | Recruiting | Houston | Texas | 77004-8004 | United States |
|
| UW Madison Clinic at Harborview | Recruiting | Seattle | Washington | 98104 | United States |
|
| 32757838 | Background | Step MM, Knight K, McMillen Smith J, Lewis SA, Russell TJ, Avery AK. Positive Peers Mobile Application Reduces Stigma Perception Among Young People Living With HIV. Health Promot Pract. 2020 Sep;21(5):744-754. doi: 10.1177/1524839920936244. Epub 2020 Aug 6. |
| 32012035 | Background | Step MM, McMillen Smith J, Kratz J, Briggs J, Avery A. "Positive Peers": Function and Content Development of a Mobile App for Engaging and Retaining Young Adults in HIV Care. JMIR Form Res. 2020 Jan 30;4(1):e13495. doi: 10.2196/13495. |
| 41843906 | Derived | Step MM, Catania LA, McMillen Smith J, Lewis SA, Bitar Y, Cheruvu VK, Berg KA, Hallam JS, Avery AK. Evaluation of the Positive Peers Mobile App for Supporting the Viral Suppression of Young People With HIV: Protocol for a Concurrent Mixed Methods Evaluation With Randomized Controlled Clinical Trial and Observational Cohort. JMIR Res Protoc. 2026 Mar 17;15:e87601. doi: 10.2196/87601. |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |