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In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. These solutions; Ethylene Diamine Tetra Acetic Acid (EDTA), Etidronic Acid and Citric Acid. The aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. Additionally, the healing of these teeth will be monitored for 1 year.
Root canal treatment is a treatment method applied to milk and permanent teeth. The inflamed and necrotic pulp where the root canal is located is cleaned, debrided chemo-mechanically, and finally filled hermetically with a biocompatible material. Necrotic immature teeth lose their restorative and defensive abilities. Since the root canal walls of these teeth are thin and weak, regenerative endodontic procedures are applied more frequently in the treatment of immature teeth to ensure root development and to restore the vitality of the pulp tissue. In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. These solutions; Ethylene Diamine Tetra Acetic Acid (EDTA), Etidronic Acid and Citric Acid. The aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. Additionally, the healing of these teeth will be monitored for 1 year.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ethylenediamine tetraacetic acid (EDTA) | Active Comparator | Regenerative endodontic treatments require the use of irrigation solutions to break down inorganic and organic tissue residues in the root canals. Sodium hypochlorite (NaOCl) and Ethylenediamine tetraacetic acid (EDTA)will be used when disinfecting root canals. (GROUP 1) |
|
| CITRIC ACID (MONO/ANH) | Active Comparator | Regenerative endodontic treatments require the use of irrigation solutions to break down inorganic and organic tissue residues in the root canals. Sodium hypochlorite (NaOCl) and CITRIC ACID (MONO/ANH) be used when disinfecting root canals. (GROUP 2) |
|
| ETİDRONİC ACID (HEBP) | Active Comparator | Regenerative endodontic treatments require the use of irrigation solutions to break down inorganic and organic tissue residues in the root canals. Sodium hypochlorite (NaOCl) and ETİDRONİC ACID (HEBP) be used when disinfecting root canals. (GROUP 3) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments | Other | Regenerative endodontic treatment using different irrigation solutions |
| Measure | Description | Time Frame |
|---|---|---|
| Determining and recording pain levels on the pain scale between treatment sessions | Evaluations close to 100 on the postoperative pain scale indicate that the severity of pain increases. Evaluations close to 0 indicate that the severity of pain has decreased. | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| In the follow-up sessions after the treatment, the size of the lesion in the bone (mm2) is measured by radiography. | Evaluations close to 100 on the scale following lesion healing indicate that the lesion size has increased. Evaluations close to 0 indicate that the lesion size has decreased. | 2 years |
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Inclusion Criteria:• Molars with open apex
Exclusion Criteria:• People with systemic disease and allergic reactions
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ERASLAN AKYÜZ | Contact | 4447138 | 0352 | ipekemamak@hotmail.com |
| ÜSTÜN | Contact | 4447138 | 0352 | yustun@erciyes.edu.tr |
| Name | Affiliation | Role |
|---|---|---|
| ERASLAN AKYÜZ | BAŞ ARAŞTIRMACI | Principal Investigator |
| ÜSTÜN | YÜRÜTÜCÜ | Study Director |
| EMİNSOY AVCI |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erciyes Üniversitesi Diş Hekimliği Fakültesi | Recruiting | Kayseri | 38039 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39815035 | Derived | Akyuz IE, Eminsoy Avci AT, Ustun Y, Kolcakoglu KS, Kizilci E. Evaluation of the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic molar teeth with open apex on postoperative pain- randomized clinical trial. Clin Oral Investig. 2025 Jan 16;29(1):66. doi: 10.1007/s00784-025-06153-3. |
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| YARDIMCI ARAŞTIRMACI |
| Study Chair |
| SOLAK KOLÇAKOĞLU | YARDIMCI ARAŞTIRMACI | Study Chair |
| KIZILCI | YARDIMCI ARAŞTIRMACI | Study Chair |
| ID | Term |
|---|---|
| D003788 | Dental Pulp Diseases |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D004492 | Edetic Acid |
| D019343 | Citric Acid |
| D012968 | Etidronic Acid |
| ID | Term |
|---|---|
| D005029 | Ethylenediamines |
| D003959 | Diamines |
| D011073 | Polyamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D000085 | Acetates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D002951 | Citrates |
| D014233 | Tricarboxylic Acids |
| D004164 | Diphosphonates |
| D063065 | Organophosphonates |
| D009943 | Organophosphorus Compounds |
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