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The use of neuromuscular blockers (NMB) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. Intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. Residual neuromuscular blockade (RNMB) is the persistence of muscle paralysis after the administration of NMB during a surgical intervention. The appearance of RNMB poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient.
The use of neuromuscular blockers (NMB) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. Intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. Residual neuromuscular blockade (RNMB) is the persistence of muscle paralysis after the administration of NMB during a surgical intervention. The appearance of RNMB poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient. In this prospective observational study, all patients who underwent general anesthesia with neuromuscular blockade were studied consecutively to evaluate the presence of residual neuromuscular blockade and its potential consequences during hospital admission.Considering that the percentage of residual curarization is 19% (PORCzero study), with a 95% confidence interval and a 3% error margin, 236 patients are needed to accurately estimate the prevalence of residual curarization in the study population. With an expected loss proportion of 20%, the chosen sample size is 296 patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients submitted to General Anesthesia with Neuromuscular Block | Patients submitted to General Anesthesia with Neuromuscular Block |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Train-of-four | Diagnostic Test | Patients submitted to general anesthesia with neuromuscular block will be monitored at their arrival to the Post-Anesthesia Care Unit to assess the presence of residual neuromuscular block. |
| Measure | Description | Time Frame |
|---|---|---|
| Residual Neuromuscular Block | Train-Of-Four ratio at arrival to the Post-Anesthetic Care Unit | 5 minutes postoperatively |
| Residual Neuromuscular Block | Train-Of-Four ratio 3 minutes after the arrival to the Post-Anesthetic Care Unit | 8 minutes postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative complications | Postoperative complications during hospital admission | 30 days postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing surgical intervention under general anesthesia that requires the use of neuromuscular block during the study time.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ángel Becerra Bolaños, PhD | Contact | +34928450370 | angbecbol@gmail.com | |
| Aurelio Rodríguez Pérez, PhD | Contact | +34928450370 | arodperp@gobiernodecanarias.org |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitario de Gran Canaria Doctor Negrín | Recruiting | Las Palmas de Gran Canaria | Las Palmas | 35010 | Spain |
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D061886 | Neuromuscular Monitoring |
| ID | Term |
|---|---|
| D008991 | Monitoring, Physiologic |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Ángel Becerra | Recruiting | Las Palmas de Gran Canaria | Las Palmas | 35019 | Spain |
|