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The goal of this observational study is to learn about EIT in observing the application of lung protective ventilation strategies in patients with pulmonary contusion, particularly the impact on pulmonary ventilation blood flow ratio, oxygen, and condition. The main question it aims to answer is:
Can lung protective ventilation strategies improve respiratory function in patients with severe chest contusion? We will collect clinical data of participants who already taking lung protective ventilation strategies as part of their regular medical care.
Trauma is the leading cause of death among middle-aged and young people in China, with over 25% of patients dying from chest trauma. The incidence of pulmonary contusion in severe chest trauma is over 70%, and it is an important cause of respiratory failure and even death in patients. The occurrence of pulmonary contusion and respiratory failure in patients with chest contusion is a dynamic process, and Regional inhomogeneities of the damaged lung should be taken into consideration to develop improved ventilation strategies. Currently, there is no ideal monitoring method to evaluate the severity of injury, and guide the ventilation strategies. Electrical impedance tomography (EIT) is a non-invasive, radiation-free imaging technique. It measures regional lung ventilation and aeration distribution by means of changes in electrical potentials at the skin surface of the chest wall during breathing cycles, which has been proven to have good practicality in patients with non-invasive ARDS and pulmonary embolism. In this study, we aim to characterize the physiologic effects of positive end expiratory pressure (PEEP) on key mechanisms of regional lung protection, namely: recruitment, reduced atelectrauma, and improved ventilation-perfusion matching, by CT scan and EIT
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EIT-PEEP group | The PEEP titration guided by EIT, decided by the responsible attending physician |
| |
| Table-PEEP group | The PEEP setting with low FiO2-PEEP table, decided by the responsible attending physician |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEEP setting strategy | Other | The attending physician selects different PEEP setting strategies |
|
| Measure | Description | Time Frame |
|---|---|---|
| ventilation blood flow ratio | ventilation blood flow ratio of lung | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| oxygenation index | oxygenation index of participant | through study completion, an average of 1 year |
| 28-day mortality | 28-day mortality |
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Inclusion Criteria:
Exclusion Criteria:
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The cohort will be selected from a tertiary hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shu Li, doctor | Contact | +86 010 88324480 | lishu2401@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Shu Li, doctor | Peking University People's Hospital | Principal Investigator |
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all collected IPD, all IPD that underlie results in a publication
starting 1 year after publication
The data used and/or analyzed during the current study are available from the Investigator on reasonable request.
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| through study completion, an average of 1 year |
| Mechanical ventilation-free from day 1 to 28 | Mechanical ventilation-free from day 1 to 28 | through study completion, an average of 1 year |
| Length of ICU stay | Length of ICU stay | through study completion, an average of 1 year |
| Length of hospital stay | Length of hospital stay | through study completion, an average of 1 year |
| The rate of successful weaning | the absence of the requirement for ventilatory support, without reintubation, a cardiac arrest event, or mortality within 48h after extubating or withdrawal | through study completion, an average of 1 year |