The aim of this study is to develop a deep learning-based application of heart sounds in the diagnosis of valvular heart disease, which can be used to screen patients with valvular heart disease and promote earlier clinical monitoring and intervention.

Inclusion Criteria:

1. age>18 years
2. In the past 1 month, echocardiography was performed to diagnose valvular heart disease (positive group) and echocardiography to exclude valvular heart disease (negative group).
3. Consent to study and be able to sign informed consent

Exclusion Criteria:

1. After prosthetic valve replacement
2. Congenital heart disease (except bilobal aortic valve)
3. Hypertrophic Cardiomyopathy（HCM）
4. Pregnant, lactating women

patients with and without valvular heart disease assessed by echocardiography