The most active members of the healthcare professionals responsible for hemodialysis units are nurses, and they have a key role in pain, anxiety and satisfaction management as they are responsible for cannulation. Therefore, complementary and integrated practices need to be implemented based on evidence to strengthen the independent role of nurses in managing pain and anxiety.

Inclusion Criteria:

• Those who are over 18 years of age,
• Able to answer questions and communicate,
• No hearing, vision or speech impairments,
• Regularly undergoing hemodialysis three times a week,
• Having arterio-venous fistula for at least 3 months,
• Having pain during needle cannulation and scoring at least two or more points on the Visual Analogue Scale (VAS),
• Having been on hemodialysis for at least three months,
• Agreeing to participate in the study with their own consent,
• Patients who are not allergic to clove oil will be included in the study.

Exclusion Criteria:

• Having neuropathic pain,
• Patients with arterio-venous fistula and loss of sensation of more than 50% in the extremity,
• Patients with infection in the arterio-venous fistula line,
• Patients with aneurysm or pseudoaneurysm in arterio-venous fistula,
• Patients who have used analgesic medication/s in the last 6 hours,
• Patients who have used sedative agent(s) in the last 6 hours,
• Patients who used local anesthetic agents before needle intervention will not be included in the study.

Pre-cannulation spray application to the intervention and placebo groups will be provided by an interviewer trained by the researchers. Cannulations will be performed by nurses in the institution where the study is conducted. Data will be collected by the responsible nurses in the institutions.

Patients participating in the study, researchers, and the nurse in charge will not know who is in the intervention and placebo groups.

The research will be completed in twelve sessions over four weeks.