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The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC). The main question it aims to answer is: Are peptidoglycan fragments from the gut microbiota associated with the progression of colorectal cancer? Participants will provide biological specimens (blood, feces, colon tissue obtained during surgery)
To explore whether peptidoglycan fragments can be used as screening or diagnostic indicators for colorectal cancer
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Colorectal Cancer(CRC) | People who are diagnosed with CRC by colonoscopy and pathological biopsy |
| |
| Colorectal adenoma(CRA) | People who are diagnosed with CRA by colonoscopy and pathological biopsy |
| |
| Colorectal polyp(CRP) | People who are diagnosed with CRP by colonoscopy and pathological biopsy |
| |
| Healthy | People who have no obvious abnormality in the whole colon |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observational study, no intervention | Other | observational study, no intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| HPLC-MS/MS was used to detect peptidoglycan fragment content in biological specimens of 200 participants | The content of peptidoglycan fragments was detected by HPLC-MS/MS | baseline (before treatment) |
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Inclusion Criteria:
Exclusion Criteria:
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Meet eligibility criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hu Mengyao | Contact | 1587088392 | 1377549166@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| He Xiaolong, Professor | Southern Medical University, China | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhujiang Hospital of Southern Medical University | Recruiting | Guangzhou | Guangdong | 510000 | China |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |