The study aims to evaluate clinical characteristics and prognostic of a contemporary population of patients with UA defined using T hs-cTn measurements The study includes all patients admitted in 2 French university centers with the confirmed diagnostic of UA defined with clinical ischemic symptoms and T hs-cTn concentrations < 99 percentile (undetectable: <5ng/l or non-elevated: <14ng/l), or ≥ 99 percentile but mildly elevated (14-50ng/l) .The primary end-point included major events at 1-year follow-up (total mortality, new ACS, hospitalization for cardiac causes).

Inclusion criteria:

• Patients with ischemic symptoms at rest or minor exercise without evidence of acute myocardial necrosis.

• Ischemic symptoms may include typical or atypical angina pectoris and worsening/deterioration of previously stable angina with or without electrical signs of ischemia on the electrocardiogram.

• hs-cTn concentrations are in the normal range or may be slightly elevated > 99th percentile (i.e. low troponin T elevation ≤ 50 * Elecsys Roche) but with absence of significant kinetics according to criteria defined in the literature (<20%).

• One of the following angiographic criteria is required:

  • Coronary angiography revealing a stenosis with a diameter of at least 70%.
  • Stenosis of at least 50% diameter in the left common trunk.
  • FFR (Fractional Flow Reserve) documenting ischemia per coronary angiography of a coronary lesion in the case of intermediate stenosis (50-70%).
  • If there are no significant lesions, a spasm must be proven by an ergonovine test.

Exclusion criteria:

• NSTEMI and STEMI.
• Coronaries normal or without significant lesions unless proven spasm.

Patients with unstable angina proven by coronary angiography admitted to Montpellier and Nîmes hospitals between November 2021 and January 2023.