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The objective of this study was to observe and evaluate the efficacy and safety of hexapopal ethanolamine tablets in the treatment of synchronous/sequential radioimmunoinduced thrombocytopenia in the real world.
The subjects of this study were patients with solid malignant tumors who had received radioimmunoinduced thrombocytopenia.
This study will retrospectively and prospectively collect real-world data related to investigational drugs, and will observe 500 patients to observe the diagnosis and treatment pattern of radiochemo-induced thrombocytopenia. The study included a screening period (no more than one week) and a treatment period (at least two cycles).Participants meeting protocol inclusion criteria were defined as having platelet values < 100×109/L during radioimmunotherapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single drug group |
| ||
| combined rhTPO group |
| ||
| combined IL-11 group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Herombopag Olamine Tablets | Drug | Herombopag Olamine;combined rhTPO;combined IL-11 |
|
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of patients recovered to 100×109/L | The proportion of patients who recovered to 100×109/L within 14 days after starting treatment with the drug was studied | 14 days after starting treatment with the study drug |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of patients recovered to 75×109/L | The proportion of patients who recovered to 75×109/L after starting treatment with the drug was studied | up to 2 months |
| Time for platelet recovery to 100×109/L |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with solid malignancies undergoing radiotherapy/chemotherapy/immunosuppressant induced thrombocytopenia
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| ID | Term |
|---|---|
| D016609 | Neoplasms, Second Primary |
| ID | Term |
|---|---|
| D009369 | Neoplasms |
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Study the time for platelet recovery to 100×109/L after drug initiation
| up to 2 months |
| Proportion of patients with treatment delay or dose reduction | Proportion of patients with delayed or reduced dose of radiotherapy, chemotherapy, immunosuppressants, etc | up to 2 months |
| TRAE | Study drug-related adverse reactions | up to 2 months |