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The study aims to predict the failure of High-flow Nasal Cannula oxygenation therapy by ultrasound evaluation of diaphragm and intercostal muscle contraction during the first 24 hours.
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| Measure | Description | Time Frame |
|---|---|---|
| Ultrasound evaluation of diaphragm | Thickness of the diaphragmatic muscle and the diaphragm thickening fraction (DTF) by ultrasound evaluation | Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment. |
| Ultrasound evaluation of intercostal muscle movement index | the parasternal intercostal muscles thickening fraction by ultrasound evaluation | Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment. |
| The patient's condition deteriorated and required noninvasive or intubated invasive mechanical ventilation. | Failing or not failing HFNC, the rate of needing noninvasive or intubated invasive mechanical ventilation. | up to 30 days after High-flow Nasal Cannula (HFNC)oxygenation therapy. |
| Measure | Description | Time Frame |
|---|---|---|
| ICU stay | patients enrolled will be followed for length of ICU stay | up to one month after High-flow Nasal Cannula (HFNC)oxygenation therapy. |
| Hospital stay | patients enrolled will be followed for length of Hospital stay |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged above 18 who are admitted to ICU will be screened for eligibility.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wei Wu | Contact | 13817976707 | wu.wei1@zs-hospital.sh.cn |
| Name | Affiliation | Role |
|---|---|---|
| Ming Zhong | Shanghai Zhongshan Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Zhongshan Hospital | Recruiting | Shanghai | Shanghai Municipality | 200032 | China |
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| up to one month after High-flow Nasal Cannula (HFNC)oxygenation therapy. |
| all cause mortality | all cause mortality | up to one month after High-flow Nasal Cannula (HFNC)oxygenation therapy. |
| Oxygen saturation | Oxygen saturation | Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment. |
| respiratory rate | respiratory rate | Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment. |
| oxygen concentration | oxygen concentration | Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment. |
| flow velocity of HFNC | flow velocity of HFNC | Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment. |
| VT | VT | Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment. |
| duration on HFNC | patients enrolled for the duration of HFNC | up to one month |