The main objective of the present study is the evaluation of the clinical efficacy of the intra-articular administration of polynucleotides in association with hyaluronic acid in the improvement of the subjective and objective manifestations of arthrosis of the temporomandibular joint compared to normal clinical management which involves Physiotherapy.

Inclusion Criteria:

• patients who signed the informed consent
• age >18;
• male and female sex;
• affected by temporomandibular arthrosis

Exclusion Criteria:

• Patients treated with painkillers and anti-inflammatories;
• patients suffering from rheumatoid arthritis with TMJ involvement;
• patients with a positive history of allergies to products of fish origin;
• patients suffering from alteration of the internal TMJ;
• patients suffering from mandibular condylar hyperplasia;
• patients suffering from myofascial pain syndrome;
• patients unable to express their consent for participation in the study;
• patients suffering from psychiatric and behavioral disorders;
• patients suffering from oncological and onco-haematological pathologies with compromised general clinical status.