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| Name | Class |
|---|---|
| Alessia Santoni | UNKNOWN |
| Sara Stottmeier | UNKNOWN |
| Klara Hemmerich | UNKNOWN |
| Giuseppe Di Dona |
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The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Occipital tACS at IAF-2Hz | Experimental | Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency below the individual alpha frequency (IAF-2 Hz). |
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| Occipital tACS at IAF+2Hz | Experimental | Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency above the individual alpha frequency (IAF+2 Hz). |
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| Frontal tACS at 4-7 Hz | Experimental | Transcranial alternating current stimulation (tACS) at frontal sites to modulate the frontal brain areas' activity at a frequency within the theta band (4-7 Hz). |
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| Sham/placebo tACS | Sham Comparator | Transcranial alternating current stimulation (tACS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective. |
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| Occipital tRNS | Experimental | Stimulation at occipital sites with transcranial random noise stimulation (tRNS) to modulate occipital brain areas plasticity |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Occipital tACS at IAF-2Hz | Procedure | tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF) |
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| Measure | Description | Time Frame |
|---|---|---|
| Behavioral measures | To study if tACS or tRNS delivered in different brain networks can modulate the learning of statistical regularities in the context of visual perception we will evaluate the following behavioral measures recorded in a computerized visual perception task: hit rate, miss, false alarms, correct rejections. These behavioral measures will allow to derive measures of sensitivity (d') and response criterion (Beta and C), according to the theoretical framework of the Signal Detection Theory (SDT). | During the procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luca Ronconi, PhD | Contact | 0226434887 | ronconi.luca@unisr.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Università Vita-Salute San Raffaele | Recruiting | Milan | 20132 | Italy |
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| UNKNOWN |
| Luigi Ferini-Strambi | UNKNOWN |
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| Frontal tRNS | Experimental | Stimulation at frontal sites with transcranial random noise stimulation (tRNS) to modulate frontal brain areas plasticity |
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| Sham/placebo tRNS | Sham Comparator | Transcranial random noise stimulation (tRNS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective. |
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| Occipital tACS at IAF+2Hz | Procedure | tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF) |
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| Frontal tACS at 4-7 Hz | Procedure | tACS applied to frontal areas at 4-7 Hz |
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| Occipital tRNS | Procedure | tRNS applied to occipital brain regions |
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| Frontal tRNS | Procedure | tRNS applied to frontal brain regions |
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| Sham/placebo tACS | Procedure | tACS is activated only for 30 seconds and then turned off, thus resulting ineffective |
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| Sham/placebo tRNS | Procedure | tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective |
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