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| Name | Class |
|---|---|
| Jacobijn Gussekloo, Prof. dr. | UNKNOWN |
| Simon P. Mooijaart, Prof. dr. | UNKNOWN |
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The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.
The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases - Enriched for familial longevity | Siblings of dutch Caucasian descent ages 75 and older | ||
| Controls - Non-enriched for familial longevity | Individuals of dutch Caucasian descent ages 75 and older solely in their family. |
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| Measure | Description | Time Frame |
|---|---|---|
| Identifying the genetic variants of Familial Longevity | To identify gene variants associated with healthy aging and protection from (multi)morbidity | through study completion, an average of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component | To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component | through study completion, an average of 2 years |
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Inclusion Criteria:
Exclusion Criteria:
-
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Dutch Caucasian descent:
Ages 75 and older, with siblings enriched for familial longevity, and individuals without a history of familial longevity
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| (Eline) P. Slagboom, Prof. dr. | Contact | +31(0)71 5269 730 | p.slagboom@lumc.nl |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Leiden University Medical Center | Recruiting | Leiden | South Holland | 2333ZA | Netherlands |
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