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The objectives of this trial are to determine whether, in critically ill ESKD patients randomization to fluid removal guided by lung and inferior vena cava ultrasound, compared to standard care, leads to Improved pulmonary congestion (primary outcome); and safety (secondary outcome) in the short-term.
The point-of-care ultrasound was thought useful in the management of fluid in critically ill patients. At present, the role of the lung and inferior vena cava ultrasound is unclear in the management of decongestion of heart failure in kidney failure (KF) patients using prolonged hemodialysis. The investigators aim to explore the effect of pre-dialysis probing with the lung and inferior vena cava to guide fluid removal as compared with conventional protocols on the improvement of heart failure symptoms in patients with KF with heart failure under prolonged hemodialysis in the short-term.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | Fluid removal with the guidance of lung and inferior vena cava ultrasound before prolonged hemodialysis |
|
| Control group | Active Comparator | Fluid removal with the conventional protocol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung and inferior vena cava ultrasound guidance | Procedure | The lung and inferior vena cava ultrasound will be utilized as guidance for the development of a dialysis prescription for prolonged hemodialysis. |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in pulmonary congestion score | within 72 hours following randomization | |
| Improvement in heart failure symptoms score | within 72 hours following randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Total ultrafiltration volume | within 72 hours following randomization | |
| Mean ultrafiltration rate during prolonged hemodialysis | within 72 hours following randomization | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Buyun Wu, PhD, MD | The First Affiliated Hospital with Nanjing Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jiangsu Province Hospital | Nanjing | Jiangsu | 210029 | China |
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| Conventional protocol guidance | Procedure | Fluid removal using conventional protocol including blood pressure and physical examination |
|
| Fluid balance (total outflow - total inflow) |
| within 72 hours following randomization |
| Lung B-line reduction | within 72 hours following randomization |
| The change of width of inferior vena cava | within 72 hours following randomization |
| Incidence of hypotension during prolonged hemodialysis | within 72 hours following randomization |
| Blood pressure variability during the prolonged hemodialysis | within 72 hours following randomization |
| In-hospital mortality | From date of randomization until the date of discharge or date of death from any cause, whichever came first, assessed up to 100 days |
| Length of hospital stay | From date of randomization until the date of discharge or date of death from any cause, whichever came first, assessed up to 100 days |
| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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