Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The study aims to determine how expression levels of biomarkers for peripheral arterial disease change over time in response to exercise therapy, surgical or endovascular intervention, and whether they can be used to predict disease progression.
Several studies have identified markers in the blood (called biomarkers) that are associated with peripheral arterial disease, or clogging up of the blood supply to the leg. There is little understanding however regarding how these respond to intervention, and how they are related to walking distance.
This study will increase the understanding of the relationship between peripheral arterial disease state and biomarker expression and enable us to work towards the development of new targets for treatment.
Participants will be invited to undertake questionnaires and dedicated walking tests alongside regular blood tests to check their biomarker levels. These will be undertaken on a regular basis so the investigators can see what happens over time, such as after a surgical procedure, and see if these markers go back towards normal following intervention.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Therapy | Patients who are advised by their clinician to undertake exercise therapy as their treatment for peripheral arterial disease | ||
| Angioplasty | Patients undergoing angioplasty for treatment of peripheral arterial disease, as advised by their clinician. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between PAD biomarker levels and walking distance. | The correlation between PAD biomarker levels and walking distance. | Baseline |
| Change in PAD biomarker levels following exercise therapy. | To investigate the change in PAD biomarker levels following exercise therapy. | 6 months up to 2 years |
| Change in PAD biomarker levels following endovascular intervention | To investigate the change in PAD biomarker levels following endovascular intervention | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| To determine whether biomarker levels normalise with improved walking distance. | Change in biomarker levels in participants with improved walking distance compared to particicpants with static or deteriorating walking distance at 6 months. | 2 years |
| To determine whether biomarker levels can be used as a predictor of restenosis, occlusion or reintervention following endovascular intervention. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Patients with peripheral arterial disease
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Phillip Stather | Contact | 01603 286286 | philip.stather@nnuh.nhs.uk |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D058729 | Peripheral Arterial Disease |
| D004194 | Disease |
| D007383 | Intermittent Claudication |
| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Compare the change in biomarkers levels pre and post angioplasty between participants requiring reintervention or occlusion, and those not requiring re-intervention or occlusion. |
| 2 years |
| Levels of biomarkers and (Major Adverse Cardiovascular Events). | The association between levels of biomarkers and (Major Adverse Cardiovascular Events). | 2 years |
| D002318 |
| Cardiovascular Diseases |
| D016491 | Peripheral Vascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |