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The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women.
The main questions it aims to answer are:
Participants will be randomly assigned to collagen or placebo groups. Participants will perform resistance training three times per week for 10 weeks and hydrolyzed collagen or maltodextrin will be given to collagen or placebo group respectively immediately before each resistance training session. Also, vitamin C will be given to both groups.
Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mechanical, and material properties of the patellar tendon and vastus lateralis muscle size and architecture will be assessed.
Young, healthy, active men and women will ingest 30 grams of hydrolyzed collagen or a calorie matched beverage (maltodextrin) alongside vitamin C prior to performing high-intensity resistance training 2 - 3 times per week for 10 weeks.
The aim of this study is to investigate the effect of combining hydrolyzed collagen supplementation with resistance training in young men and women. If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance.
The experimental design and measurements will be the same in the Arm 1 and Arm 2 but the differences will be sex where participants in Arm 1 will be healthy young men while participants in Arm 2 will be healthy young women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resistance training with hydrolyzed collagen ingestion in healthy young men | Experimental | Healthy young men, pair-matched by age, body mass, height, and baseline strength, will be randomly allocated to the collagen (COL) or placebo (PLA) group. Pre- and post-training assessments are patellar tendon properties, maximal knee flexor and extensor strengths and vastus lateralis muscle morphology using an isokinetic dynamometer and ultrasound scan. Participants will perform the 10-week progressive resistance training program three times per week and training loads will be adjusted weekly based on the prior session's performance. In each session, two different calorie-matched beverages were given immediately before the start of resistance training. 30 grams of hydrolyzed collagen (HC) and 30.5 grams of maltodextrin were used for COL and PLA respectively. HC or maltodextrin was mixed with 250 milliliters of water, 50 milligrams of vitamin C and 3 grams non-caloric sweetener which was used to mask flavour in an opaque bottle. |
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| Resistance training with hydrolyzed collagen ingestion in healthy young women | Experimental | The intervention procedure is the same as for Arm 1 except that the participants will be healthy young women (not men). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance training with hydrolyzed collagen ingestion in healthy young men | Dietary Supplement | Participants in this intervention will be healthy young men. The information of nutritional supplements is below. Hydrolyzed collagen: 30 grams unflavored hydrolysed collagen (HC) (Myprotein, Cheshire, UK) 30.5 grams unflavored maltodextrin (Myprotein, Cheshire, UK) 50 milligrams vitamin C powder (Holland and Barrett Retail Limited, Warwickshire, UK) 3 grams non-caloric sweetener (Truvia®, SilverSpoon, London, UK) |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal knee extensor (quadriceps) muscle strength | Using isokinetic dynamometer, knee extensor maximal isometric voluntary contraction torque (in Newton meters) will be measured. | 12 weeks (10 weeks' intervention plus one week either side for assessments) |
| Maximal knee flexor (hamstring) muscle strength | Using an isokinetic dynamometer, knee flexor maximal isometric voluntary contraction torque (in Newton meters) will be measured. | 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments) |
| Patellar tendon cross-sectional area | Using ultrasonography, patellar tendon cross-sectional area (in millimeters squared) will be measured. | 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments) |
| Patellar tendon stiffness | Using ultrasonography, patellar tendon stiffness (in Newtons per millimeter) will be measured. | 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments) |
| Vastus lateralis (VL) muscle size | Using ultrasonography, the VL anatomical cross-sectional area (in centimeters squared) will be measured. | 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments) |
| Vastus lateralis (VL) muscle fascicle length | Using ultrasonography, VL muscle fascicle length (in millimeters) will be measured. | 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Institute for Sport and Exercise Sciences | Liverpool | Merseyside | L3 3AF | United Kingdom |
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The study design is a single-blind (participants were unaware of their group allocation), randomized controlled trial.
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| Resistance training with hydrolyzed collagen ingestion in healthy young women | Dietary Supplement | Participants in this intervention will be healthy young women. The same nutritional supplements in Arm 1 wil be used in Arm 2. |
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| Vastus lateralis (VL) muscle fascicle pennation angle | Using ultrasonography, VL muscle fascicle pennation angle (in degrees) will be measured. | 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments) |
| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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