The purpose of the study is to determine if intranasal dexmedetomidine could be an alternative to the current standard of care (injectable benzodiazepines or antipsychotics) for sedation prior to computerized tomography (CT) or magnetic resonance imaging (MRI) in those greater than or equal to 65 years of age (older adults) that are seen in the Emergency Department (ED).

Inclusion Criteria:

• 65 years of age and older
• Patients in need of sedation prior to either a computerized tomography (CT) or magnetic resonance imaging (MRI)

Exclusion Criteria:

• Patients who weigh < 50 kg
• Cardiac arrhythmias or QTc >450
• Intravenous access not standard of care or unable to obtain
• Patients with any allergies or contraindications to dexmedetomidine, haloperidol (i.e. patients diagnosed with Parkinson's) or lorazepam
• Patients with low blood pressure, defined as a less than 100/60 mmHg
• Patients with bradycardia (Heart rate < 60 bpm)
• Patients presenting with chief complaint of respiratory distress/failure
• Intranasal administration contradictions: nasal septal abnormalities, nasal trauma, epistaxis, excessive nasal mucus or blood, and intranasal damage, recent use of nasally administered vasoconstrictors such as cocaine, oxymetazoline, and phenylephrine