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The post-hepatotectomy liver failure (PHLF) is still the most worrisome complication of hepatic resection. Surgeons have always been making efforts to preoperatively predict PHLF using kinds of techniques, scoring systems, and variables. The investigators of this study tried to create an individual predictive model based on the variable, resected normal parenchymal volume (RNLV), then assessing the performance and value of the model in clinical practice.
The investigator launched a large sample-size and retrospective study, enrolling more than a thousand consecutive patients diagnosed with hepatocellular carcinoma (HCC) and intracholangiocarcinoma (ICC) underwent hepatotectomy from the investigator's center. The primary aim of study was to identify whether there was strong correlation between RNLV and PHLF, and the second aim was to further build a combination model based on RNLV and evaluate the value of predicting PHLF in clinical practice. The investigators attached same importance to RNLV, compared to future liver remnant, especially for patients with massive tumors and multiple tumors. The investigators hyperthesized that RNLV could be an indicative variable for surgical safety, and help to form a diversifying method to comprehensively assess the risk of PHLF preoperatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PHLF group | One group was defined as post-operative liver failure accroding to the PHLF definition of 50-50 criteria and ISGLS criteria. |
| |
| No PHLF group | One group was defined as no post-operative liver failure accroding to the PHLF definition of 50-50 criteria nor ISGLS criteria. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| the different definitions of PHLF according to 50-50 criteria and ISGLS criteria | Diagnostic Test | Our study respectively defined the PHLF according to the 50-50 criteria and the ISGLS criteria in literature review. |
| Measure | Description | Time Frame |
|---|---|---|
| Probability of PHLF was predicted with our individual model based on RNLV. | In our center, an increase international normalized ratio greater than 1.15 and concomitant hyperbilirubinemia more than 23μmol/L on or after postoperative day 5 would be defined as PHLF, according to the International Study Group of Liver Surgery. | postoperative day 1 to day 30. |
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Inclusion criteria:
Exclusion criteria:
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1133 consecutive patients diagnosed with hepatocellular carcinoma (HCC) and intracholangiocarcinoma underwent hepatectomies.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yuan-yuan Wang | Contact | +8615800332525 | wangyuanyuan702@foxmail.com | |
| Gang Huang | Contact | +8613918663457 | squaror@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yuan-yuan Wang | Eastern Hepatobiliary Surgery Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mengchao Hepatobiliary Hospital of Fujian Medical University | Recruiting | Fujian | Shanghai Municipality | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31145929 | Background | Ioannou GN, Green P, Kerr KF, Berry K. Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification. J Hepatol. 2019 Sep;71(3):523-533. doi: 10.1016/j.jhep.2019.05.008. Epub 2019 May 28. | |
| 32832496 | Background | Xie DY, Ren ZG, Zhou J, Fan J, Gao Q. 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights. Hepatobiliary Surg Nutr. 2020 Aug;9(4):452-463. doi: 10.21037/hbsn-20-480. |
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After we published our study paper, we would like to share IPD attached to our paper as website links.
After our paper published officially. The final time would be end of March 31st,2024.
Not sure now.
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| The Third Affiliated Hospital of Naval Medical University | Recruiting | Shanhai | Shanghai Municipality | 201800 | China |
|
| Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen, Mengchao Hepatobiliary Hospital of Fujian Medical University | Recruiting | Shenzhencun | Shanghai Municipality | China |
|
| 26627084 | Background | Renner P, Schuhbaum J, Kroemer A, Zeman F, Loss M, Lang SA, Geissler EK, Schlitt HJ, Farkas SA. Morbidity of hepatic resection for intermediate and advanced hepatocellular carcinoma. Langenbecks Arch Surg. 2016 Feb;401(1):43-53. doi: 10.1007/s00423-015-1359-y. Epub 2015 Dec 1. |
| 32988708 | Background | Xie QS, Chen ZX, Zhao YJ, Gu H, Geng XP, Liu FB. Systematic review of outcomes and meta-analysis of risk factors for prognosis after liver resection for hepatocellular carcinoma without cirrhosis. Asian J Surg. 2021 Jan;44(1):36-45. doi: 10.1016/j.asjsur.2020.08.019. Epub 2020 Sep 28. |
| ID | Term |
|---|---|
| D017093 | Liver Failure |
| ID | Term |
|---|---|
| D048550 | Hepatic Insufficiency |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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