Direct Oral Anticoagulants and Management of Blleding Following Dental Extractions. A Prospective Cohort Study.

Direct Oral Anticoagulants and Management of Blleding Following Dental Extractions. A Prospective Cohort Study.

Evaluation of DOACs treatment on post-extraction bleeding

Consecutive patients requiring at least one dental extraction were enrolled. DOACs regimen was either maintained or suspended. Patients were classified in subgroups depending on the number of teeth extracted per procedure (≤ 3 or > 3), the need for flap raising and the performance of osteotomy. Bleeding was recorded intraoperatively, perioperatively at 20, 40, 60 and 80 minutes after the procedure, and in the first seven days post-operatively.

Inclusion Criteria:

• age >18 years
• patients under pharmacological treatment with DOACs
• patients requiring at least one dental extraction
• patients willing to take part in the study and to sign informed consent

Exclusion Criteria:

• patients below 18 years of age
• patients treated with antiplatelet therapy or vitamin K antagonists
• patients presenting with an International Normalized Ratio (INR) >3.0
• patients suffering from congenital or acquired coagulopathies (e.g. haemophilia, coagulation factors deficiency, von Willebrand disease, thrombocytopenia, cirrhosis)