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The goal of this observational study is to develop a machine learning algorithm for early detection of infections in kidney transplant recipients using data recorded by wearable digital health technologies.
The main questions it aims to answer are:
Participants will be given/use their own wearable device that will record biometric data. Any infection event will be recorded and an algorithm will be trained to recognize changes in biometric data preceding symptomatic infection.
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| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of the algorithm at detecting infections at presymptomatic stage | Accuracy, sensitivity, specificity, negative and positive predictive value of the machine learning algorithm at detecting infections in presymptomatic stage in kidney transplant recipients. | The primary endpoint will be assessed periodically throughout the study, up to 24 months. |
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| Measure | Description | Time Frame |
|---|---|---|
| Rate of in-patient admissions | Any hospital admission for infection treatment is considered an event of this outcome | Periodically throughout the study, up to 24 months. |
| Incidence of decrease/increase of Quality of Life |
Inclusion Criteria:
Exclusion Criteria:
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Kidney transplant recipients followed at the Institute for Clinical and Experimental Medicine.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vojtech Petr, MD | Contact | 720-639-0909 | petv@ikem.cz |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute for Clinical and Experimental Medicine | Prague | 14021 | Czechia |
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| ID | Term |
|---|---|
| D007239 | Infections |
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plasma, serum at enrollment and then ad hoc at infection event
Score change of WHOQOL-BREF from baseline.
| Periodically throughout the study, up to 24 months. |