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The purpose of this study is to investigate the preliminary surgical outcomes of laparoscopic right hemicolectomy with transrectal specimen extraction. The hypothesis is that this type of natural orifice specimen extraction surgery (NOSES) could achieve good short-term and oncological outcomes for right colon cancer patients.
This study is a prospective single-arm clinical study. 37 patients with right colon cancer undergoing laparoscopic right hemicolectomy with transrectal specimen extraction are planned to be included in the study. The purpose of this study is to investigate the preliminary surgical outcomes of laparoscopic right hemicolectomy with transrectal specimen extraction. The primary endpoint is the postoperative complications of this type of natural orifice specimen extraction surgery (NOSES). The primary hypothesis is that NOSES could reduce postoperative complications. In addition, operating time, intraoperative bleeding, post-operative recovery and quality of life (QoL) are secondary endpoints.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparoscopic Right Hemicolectomy With Transrectal Specimen Extraction | Experimental | STEP 1: Dissection and separation The mesentery and vessels were dissected and separated according to the principle of complete mesocolic excision. STEP 2: Intracorporeal anastomosis An enterotomy was performed on the antimesenteric side of the ileum at the edge of the staple line. This maneuver was replicated on the transverse colic side. Subsequently, the cartridge jaw of the stapler was inserted into the transverse colon. The stapler was fired and withdrawn, and the common enterotomy was sealed by using another linear stapler. STEP 3: Transrectal specimen extraction A longitudinal incision was made on the anterior of wall of the upper rectum. The assistant employed oval forceps to extract the specimen along with the protective sleeve through the incision in the upper rectum. After the complete extraction of the specimen, a full-layer running suturing was performed to close the incision. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic right hemicolectomy with transrectal specimen extraction | Procedure | Laparoscopic right hemicolectomy with transrectal specimen extraction |
|
| Measure | Description | Time Frame |
|---|---|---|
| The rate of postoperative complications | The rate of postoperative complications = patients with any postoperative complications/all cases. | up to 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Operating time | Operating time = The Operative time was defined as the time first skin incision was made to final skin closure | up to 1 days |
| Estimated blood loss | Estimated blood loss = The sum of the blood in the suction canister (the total volume after subtracting the amount of irrigation fluid used) and the segment of increased weight of swabs used during operation phase (1 ml of blood is about weighs 1g) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zheng Xu, M.D. | Contact | +8618800157037 | 1206164395@qq.com | |
| Yueyang Zhang, M.D. | Contact | +8613552910035 | yyzhang0129@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Haitao Zhou, M.D. | National Cancer Center, China | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Cancer Center | Recruiting | Beijing | Beijing Municipality | 100000 | China |
Participants' data are only allowed to be used for the analysis of this study and are not authorized to be shared with other researchers.
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| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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| up to 1 days |
| The time of first flatus | The time of first flatus = The time of first flatus reported by patients | up to 5 days |
| Postoperative hospitalization | Postoperative hospitalization = the number of nights from surgery to discharge | up to 30 days |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |