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The goal of this observational study is to compare the CMV infection and reactivation after allogeneic hematopoietic stem cell transplantation Between Standard Regimen, Methotrexate plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen. The main questions it aims to answer are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| standard GVHD prophylaxis | calcineurin inhibitor (cyclosporin A ;CSA) and methotrexate (MTX) | ||
| posttransplant cyclophosphamide (PTCy) |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with CMV infection and reactivation | Number of participants with CMV infection and reactivation after allogeneic hematopoietic stem cell transplantation Between Standard Regimen, Methotrexate plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen | 14 days to 6 months after transplant |
| Measure | Description | Time Frame |
|---|---|---|
| progression-free survival | at 2 years after transplant | |
| Median overall survival | at 2 years after transplant | |
| cumulative incidence of relapse |
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Inclusion Criteria:
Exclusion Criteria:
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allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chutima Kunacheewa, MD | Contact | +6624197000 | chutima.kua@mahidol.ac.th | |
| Weerapat Owatthanapanich, MD | Contact | +6624197000 | weerapat.owa@mahidol.ac.th |
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Need a consensus from colleagues
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| at 2 years after transplant |
| non-relapsed mortality | at 2 years after transplant |
| GvHD | Number of participants who have GvHD symptom | at 2 years after transplant |
| Averse events | Averse events of GVHD prophylaxis medication | at 2 years after transplant |
| ID | Term |
|---|---|
| D003586 | Cytomegalovirus Infections |
| ID | Term |
|---|---|
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
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