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The goal of this clinical trial is to evaluate the tolerability, pharmacokinetics and pharmacodynamics of Ethoximod in healthy subjects. The main questions it arms to answer are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Placebo Tablet |
|
| test drug | Experimental | Ethoximod Tablet, 5mg and 10mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ethoximod | Drug | Ethoximod is a S1P1 modulator. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Peak plasma concentration (Cmax) | Up to 64 days | |
| Time to peak plasma concentration (Tmax) | Up to 64 days | |
| The lowest plasma concentration (Cmin) | Up to 64 days | |
| Half-life (t1/2) | Up to 64 days | |
| Number of adverse events and number of participants with adverse events | Up to 64 days |
| Measure | Description | Time Frame |
|---|---|---|
| Lymphocyte count | Up to 64 days | |
| Percentage of CD3+CD4+ and CD3+CD8+ T cells | Up to 64 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The first hospital of Jilin University | Changchun | Jilin | China |
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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