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| Name | Class |
|---|---|
| Providence Health & Services | OTHER |
| Vancouver Coastal Health | OTHER_GOV |
| Fraser Health | OTHER |
| Interior Health |
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The goal of this stepped-wedge cluster randomized trial is to assess the impact of a laboratory test overuse intervention bundle on laboratory test utilization in 6 health authorities (16 hospitals) in British Columbia. The main question it aims to answer is if the intervention bundle, inclusive of healthcare provider and patient engagement tools, can be effectively implemented for hospitalized medical inpatients in 16 hospitals across BC and reduce laboratory test over-use. Researchers will compare hospital clusters that receive the intervention at different (sequential) time points to see if there are significant changes in the measured outcomes after the intervention.
This study aims to reduce unnecessary laboratory test use in hospitals using a stepped-wedge cluster randomized trial design. Over-use of laboratory testing in hospitals leads to patient discomfort, disruption of sleep patterns, and is associated with hospital-acquired anemia. The specific tests that the investigators focus on are complete blood count, electrolytes, creatinine, urea, international normalized ratio and partial thromboplastin time. After the initial control period, the investigators will begin with a pilot-phase for a feasibility assessment of the intervention tools. The intervention bundle will then be rolled out sequentially, one cluster (each cluster containing 2-3 hospitals) at a time in 12-week implementation steps.
The intervention bundle will contain tools to promote education around appropriate use of laboratory testing in hospitals (using an online module, clinical decision support tool), will share data on laboratory test utilization patterns locally, and include patient engagement materials (infographic and video).
Local champions in hospitals will form multidisciplinary implementation teams to facilitate adaptation and delivery of implementation tools within local context. A pragmatic stepped-wedge design will be used to implement the intervention bundle in 16 hospitals grouped into 8 clusters.
The first 4 weeks of implementation will be a pre-intervention period, trialing and adapting tools to the local context. Readiness assessments and workflow observations will be conducted to understand organizational readiness for implementation. Clusters will enter the intervention period during the latter 8 weeks of the implementation period where intervention tools will be deployed.
Data will be collected for at least 24 weeks post-implementation, evaluating the impact of tools without dedicated personnel support. Access to educational resources will continue, and laboratory utilization reports will be sent.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention Arm (Intervention Bundle Implementation) | Experimental | This arm involves the time periods of the hospital units where the LTO bundle, including healthcare provider and patient engagement tools, is actively implemented. |
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| Control Arm (No LTO Bundle Implementation) | No Intervention | This arm represents the time period of hospital units where the LTO bundle is not implemented. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laboratory test overuse (LTO) Bundle | Behavioral | Key Components of the LTO Bundle: Educational materials, including an online module, clinical decision support tool, provision of lab utilization (Audit and Feedback) reports for healthcare providers. Patient engagement tools, such as videos and educational infographics. System level implementation tools adapted to the local context, including EMR-based tools and order set changes, etc. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in number of target laboratory tests ordered per patient-day with LTO bundle compared to control period without LTO bundle | The change in the number of the six target laboratory tests with the LTO bundle | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Change in number of total laboratory tests ordered per patient-day with the LTO bundle | Change in the number of all common laboratory tests ordered during the study with the LTO bundle | 3 years |
| Rate of hospital re-admissions and mortality |
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Participants involved in this study include the following groups: patients and healthcare providers (including learners, physicians and allied health staff)
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anshula Ambasta | Contact | 4036184586 | anshula.ambasta@ubc.ca |
| Name | Affiliation | Role |
|---|---|---|
| Anshula Ambasta | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Northern British Columbia | Recruiting | Prince George | British Columbia | V2M 1S2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38956637 | Derived | Ambasta A, Holroyd-Leduc JM, Pokharel S, Mathura P, Shih AW, Stelfox HT, Ma I, Harrison M, Manns B, Faris P, Williamson T, Shukalek C, Santana M, Omodon O, McCaughey D, Kassam N, Naugler C. Re-Purposing the Ordering of Routine Laboratory Tests in Hospitalized Medical Patients (RePORT): protocol for a multicenter stepped-wedge cluster randomised trial to evaluate the impact of a multicomponent intervention bundle to reduce laboratory test over-utilization. Implement Sci. 2024 Jul 2;19(1):45. doi: 10.1186/s13012-024-01376-6. |
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| ID | Term |
|---|---|
| D007049 | Iatrogenic Disease |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| INDUSTRY |
| Northern Hospital, Australia | OTHER |
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
| Island Health | OTHER |
Intervention Arm (Intervention Bundle Implementation):
This arm involves the time periods where hospital units are actively receiving the intervention bundle, including healthcare provider (HCP) and patient engagement tools.
Control Arm (No Intervention Bundle Implementation):
This arm represents the time periods when the hospital units do not receive the intervention bundle. This time period is the control period. Each hospital will contribute to intervention and control period data.
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Rate of hospital re-admission and mortality rates over study period with LTO intervention bundle
| 3 years |
| Change in costs associated with routine laboratory testing | Change in costs associated with routine laboratory testing | 3 years |
| Mount St. Joseph's Hospital | Recruiting | Vancouver | British Columbia | V5T3N4 | Canada |
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| Vancouver General Hospital | Recruiting | Vancouver | British Columbia | V5Z1N1 | Canada |
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| St. Paul's Hospital | Recruiting | Vancouver | British Columbia | V6Z 1Y6 | Canada |
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