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To evaluate the association between time from PCI to cancer surgery and cardiovascular and oncologic outcomes in early-stage cancer patients, A retrospective, population-based cohort study was conducted using data from the Korean National Health Insurance Service (K-NHIS) database.
Early-stage-cancer patients with a history of PCI who underwent cancer surgery (N = 3621) were included. The patients were divided into two groups based on the time between the dates of PCI and cancer surgery (<12 months and ≥12 months). Patients were stratified into early-surgery and late-surgery, defined as patients who underwent surgery ≥1 and <1 month after cancer diagnosis. Outcomes included bleeding, spontaneous myocardial infarction (MI), repeat revascularization, cancer recurrence, and death.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Time between the dates of PCI and cancer surgery <12 months | Time between the dates of PCI and cancer surgery <12 months | ||
| time between the dates of PCI and cancer surgery ≥12 months | time between the dates of PCI and cancer surgery ≥12 months |
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| Measure | Description | Time Frame |
|---|---|---|
| Occurence of Bleeding | Bleeding requiring transfusion was defined by the transfusion codes (X2021, X2022, X2031, X2032, X2091, X2092, X2111, X2112, X2131, X2132). | up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of Spontaneous myocardial infarction | Spontaneous myocardial infarction (MI) was defined as hospitalization for MI (ICD-10 codes I21 and I22) | up to 5 years |
| Occurence of Repeat revascularization |
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Inclusion Criteria:
Exclusion Criteria:
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Early-stage cancer patients who underwent PCI before the cancer surgery.
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40240888 | Derived | Choi KH, Lee J, Lee J, Cho J, Kang D, Kim HK. Association Between Time From Percutaneous Coronary Intervention to Cancer Surgery and Cardiovascular and Oncological Outcomes. J Am Heart Assoc. 2025 May 6;14(9):e038569. doi: 10.1161/JAHA.124.038569. Epub 2025 Apr 16. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Repeat revascularization was defined as the presence of a procedure code after cancer surgery.
| up to 5 years |
| Occurence of Cancer recurrence | Cancer recurrence was defined as the presence of chemotherapy and/or radiation therapy that began more than 6 months after surgery completion. | up to 5 years |
| Occurence of All cause death | Vital status was obtained from death certification collected by Statistics Korea at the Ministry of Strategy and Finance of South Korea. | up to 5 years |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |