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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01DA056415 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Opioid use disorder (OUD) group | Other | This group takes buprenorphine and has OUD. |
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| Buprenorphine (BUP) control group: | Other | This group takes BUP and does not have OUD. |
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| Healthy Controls group | Other | This group does not take BUP and does not have OUD. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic Resonance Imaging (MRI) | Other | Enrolled participants will have one MRI during the study on day 2 after having Day 1 visit. During the MRI the participants will complete various tasks. |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in Blood Oxygen Level Dependent (BOLD) signal in the hippocampus | BOLD signal during functional magnetic resonance imaging (fMRI) will be used as a measure of hippocampus activation when remembering common objects and scenes. The study team will examine differences between participants with Opioid Use Disorder (OUD) and those without OUD. | Day 2 (MRI task visit) |
| Differences in Hippocampal (Hpc) volume | T-1 weighted structural images for each participant will be used to compute the volume of the hippocampus in people with OUD compared to those without OUD. | Day 2 (MRI task visit) |
| Differences in hippocampal circuit connectivity | Functional connectivity, measured with BOLD signal will be used to examine functional connectivity between the hippocampus, amygdala, and prefrontal cortex. The study team will examine differences in connectivity between participants with OUD and those without OUD. | Day 2 (MRI task visit) |
| Differences in performance | Number of correct responses will be used to assess memory for common objects and scenes. Differences in memory will be examined in between participants with OUD and those without OUD. | Day 1 (computer tasks visit) |
| Differences in performance | Number of correct responses will be used to assess memory for common objects and scenes. Differences in memory will be examined in between participants with OUD and those without OUD. | Day 2 (MRI task visit) |
| Differences in threat reactivity measured via skin conductance response (SCR) |
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Inclusion Criteria for all groups:
Inclusion Criteria for Opioid Use Disorder (OUD) group:
Inclusion Criteria for the BUP control group:
Inclusion Criteria for Healthy participant group:
Exclusion Criteria for all groups:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aml Almamri | Contact | 734-232-0190 | AdversityBrainOUD@med.umich.edu | |
| Madeline Vincent | Contact | 734-232-0190 | AdversityBrainOUD@med.umich.edu |
| Name | Affiliation | Role |
|---|---|---|
| Elizabeth Duval | University of Michigan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Recruiting | Ann Arbor | Michigan | 48109 | United States |
It is NIH policy that the results and accomplishments of the activities that it funds should be made available to the public. The principal investigator (PI) will ensure all mechanisms used to share data will include proper plans and safeguards for the protection of privacy, confidentiality, and security for data dissemination and reuse (e.g., all data will be thoroughly de-identified and will not be traceable to a specific study participant). Plans for archiving and long-term preservation of the data will be implemented, as appropriate.
When the study is completed, access to study data will be provided by the PI as requested.
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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| Computer Tasks | Behavioral | Eligible participants will complete computer tasks (cognitive tasks, spatial navigation tasks, context dependent fear learning, etc.) at visit 1 and then during the MRI. |
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Electrodermal activity collected with a bioamplifier will be used to quantify physiological reactivity to threat. Event related SCR will be measured as a baseline corrected response (peak minus baseline) to cues that predict threat compared to cues that do not predict threat. Differences in SCR between participants with OUD and participants without OUD will be examined.
| Day 1 (computer tasks visit) |
| Differences in threat reactivity measured via skin conductance response (SCR) | Electrodermal activity collected with a bioamplifier will be used to quantify physiological reactivity to threat. Event related SCR will be measured as a baseline corrected response (peak minus baseline) to cues that predicted threat on the previous day compared to cues that did not predict threat. Differences in SCR between participants with OUD and participants without OUD will be examined. | Day 2 (MRI task visit) |