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The prevalence of postpartum depression (PPD) varies between 11.9% and 19.2% during the perinatal period. PPD refers to minor and major depression incidents that occur during pregnancy or shortly after (up until 12 months after birth). The symptoms of PPD embrace feeling sad or having a depressed mood, being uninterested in the new-born, unreasonable crying and fear of injuring or harming the baby. Consequently, PPD can negatively impact the mother's well-being and the baby's development. The impact on a child can be short for cognitive and motor development . Although medication is a feasible alternative, many women have constraints due to continuing breastfeeding. Therefore, exercise can be an alternative that could help to deal with PPD. Exercise can be used as a preventive or treatment of mild depression at an early stage and as an addition to a treatment plan for major depressive disorder. Exercising during pregnancy and postpartum improves psychological health and also benefits physical fitness, weight gain control and the prevention or reduction of musculoskeletal discomfort and pain. Therefore, the American College of Obstetrics and Gynaecologists has recommended that women during pregnancy and postpartum engage in moderate-intensity physical activity almost every day for 30 min a day
The prevalence of postpartum depression (PPD) varies between 11.9% and 19.2% during the perinatal period. PPD refers to minor and major depression incidents that occur during pregnancy or shortly after (up until 12 months after birth). The symptoms of PPD embrace feeling sad or having a depressed mood, being uninterested in the new-born, unreasonable crying and fear of injuring or harming the baby. Consequently, PPD can negatively impact the mother's well-being and the baby's development. The impact on a child can be short for cognitive and motor development . Although medication is a feasible alternative, many women have constraints due to continuing breastfeeding. Therefore, exercise can be an alternative that could help to deal with PPD. Exercise can be used as a preventive or treatment of mild depression at an early stage and as an addition to a treatment plan for major depressive disorder. Exercising during pregnancy and postpartum improves psychological health and also benefits physical fitness, weight gain control and the prevention or reduction of musculoskeletal discomfort and pain. Therefore, the American College of Obstetrics and Gynaecologists has recommended that women during pregnancy and postpartum engage in moderate-intensity physical activity almost every day for 30 min a day
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| exercise | Active Comparator | aerobic exercise during pregnancy |
|
| no exercise | No Intervention | no recommendation regarding exercise |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise in pregnancy | Behavioral | aerobic exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| edinburgh depression scale | Edinburgh Postnatal Depression Scale (EDPS) | 3 months after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Postpartum depression | DSM-5 (SCID-5) | 3 months after delivery |
| preterm birth | defined as delivery before 37 weeks of gestation | 37 weeks of gestation |
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Inclusion Criteria:
Exclusion Criteria:
pregnant women
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gabriele Saccone, MD | Contact | 3394685179 | gabriele.saccone.1990@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gabriele Saccone | Recruiting | Naples | 80100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41527031 | Derived | Saccone G, Perrino C, Bardi L, Fico V, Ilardi F, Motta M, Sarno L, Di Spiezio Sardo A, Esposito G, Bifulco G. Exercise in pregnancy and maternal cardiovascular changes. BMC Pregnancy Childbirth. 2026 Jan 13;26(1):177. doi: 10.1186/s12884-026-08637-w. | |
| 40976261 | Derived | Saccone G, Buonomo G, Ammendola A, Bardi L, Motta M, Gragnano E, Locci M. Exercise in Pregnancy and Risk of Postpartum Depression: A Randomised Controlled Trial. BJOG. 2026 Jan;133(2):211-217. doi: 10.1111/1471-0528.70010. Epub 2025 Sep 21. |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D011247 | Pregnancy |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Exercise during pregnancy
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| D012098 | Reproduction |
| D055703 | Reproductive Physiological Phenomena |
| D012101 | Reproductive and Urinary Physiological Phenomena |