Peripheral Central Catheter (PICC) is one of the painful interventions that are routinely performed repeatedly to establish a safe venous access in preterm babies.Nurses should reduce the pain of babies and ensure their comfort during interventions arising from the necessity of care processes.

Today, it is accepted that tactile stimuli, which have a pain-reducing effect on babies, should be used as a complementary treatment and care method. Palmar grasp reflex is one of the important tactile stimuli to reduce pain and provide comfort in babies. This research will be conducted to examine the effect of palmar grasp reflex stimulation on pain and comfort levels in PICC care in preterm babies.

Inclusion Criteria:

• Without congenital defects,
• Not receiving sedation at least 3 hours before PICC care,
• No unexplained crying,
• Without neurological problems,
• Not undergoing surgical intervention,
• Babies with PICC insertion

Exclusion Criteria:

• Having had a painful procedure (invasive procedure, etc.) within the last hour,
• Babies for whom permission was not obtained from the parent through an informed voluntary consent form