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qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia.
No trials have compared them, so with this trial authors want to explore the correlations between them.
qNOX and ANI are two indexes evaluting the anaglesia conduction during general anesthesia.
Even if the aim is the same (to measure the nociception level) these indexes utilize different algorithm: the qNOX is derived by the electroencephalogrm (EEG), the ANI is derived by heart rate variation.
No trials have compared them, so with this trial authors want to explore the correlations between them, and if altered values of one of them is stronger related to postoperative pain and delirium.
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| Measure | Description | Time Frame |
|---|---|---|
| Correlation between qNOX and ANI values | qNOX and ANI values will be compared to check the correspondance in evaluting analgesia level | qNOX, ANI, pupoillometry values, propofol and remifentanil concentration during induction, intubation, after post-tetanic count at the trend-of-four and maintenance phase of general anesthesia detected with target controlled inusion will be paired. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between qNOX from CONOX and Analgesia nocicpetion index (ANI) values and postoperative pain | Evaluate if qNOX or ANI values relate to postoperative pain | qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative pain, evalued with NRS score after 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Women undergoing brast cancer surgery with general anesthesia with Propofol and remifentanil TCI will be recruited
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Treviso Regional Hospital | Treviso | TV | 31100 | Italy |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Correlation between qNOX from CONOX and analgesia nocicpetion index (ANI) values and postoperative delirium | Evaluate if qNOX or ANI values relate to postoperative delirium | qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative delirium, evaluated with CAM and 4AT score after 24 hours |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |