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This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and white matter changes under microgravity exposure, screen and identify representative image markers, so as to provide decision-making information for the cognitive status changes of relevant personnel under microgravity environment.
MRI has the advantage of non-invasive and non-radiation, and imaging the human brain after exposure to microgravity can reveal the neuroplastic changes in the astronaut's brain and discover the characteristics of functional activities behind it. The purpose of this study is to explore the image features and cognitive state related information related to the changes of human brain neuroplasticity under microgravity environment, and to identify the related image markers. At the same time, the pathophysiological mechanism is preliminarily discussed in this study. This study is helpful for us to explore the sensitivity of different brain structures and brain functions to space microgravity environment, so as to further understand the role and influence of space missions on brain health.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Head-Down tilt Bed Rest test | Other | All of the volunteers underwent 60 days of the Head-Down tilt Bed Rest test. |
| Measure | Description | Time Frame |
|---|---|---|
| Local brain functional activity | Based on resting-state functional MRI images, the changes of local brain functional activity before and after the Head-Down tilt Bed Rest test were compared. | 60 days after the Head-Down tilt Bed Rest test |
| Brain functional connectivity | Based on resting-state functional MRI images, the changes of brain functional connectivity before and after the Head-Down tilt Bed Rest test were compared. | 60 days after the Head-Down tilt Bed Rest test |
| Brain structure - Morphology | Based on 3D-T1WI, the changes of brain structure before and after the Head-Down tilt Bed Rest test were compared. | 60 days after the Head-Down tilt Bed Rest test |
| Brain fiber bundle and brain Diffusion index | Based on diffusion tensor imaging, the changes of brain fiber bundle and brain diffusion index before and after the Head-Down tilt Bed Rest test were compared. | 60 days after the Head-Down tilt Bed Rest test |
| Brain blood flow | Based on arterial spin labeling, the changes of brain blood flow before and after the Head-Down tilt Bed Rest test were compared. | 60 days after the Head-Down tilt Bed Rest test |
| Imaging indexes and clinical scale scores | Based on the changes of relevant imaging indexes and the changes of relevant clinical scale scores, explore the correlation between the changes of relevant imaging indexes and relevant clinical scales scores. | 60 days after the Head-Down tilt Bed Rest test |
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Inclusion Criteria:
Exclusion Criteria:
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Volunteers who underwent 60 days of the Head-Down tilt Bed Rest test.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chinese PLA General Hospital | Beijing | China |
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