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| Name | Class |
|---|---|
| National Natural Science Foundation of China | OTHER_GOV |
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To breakthrough the bottleneck identified, we will conduct a cross-sectional study to develop a symptom clustering model for depression and anxiety. A wide range of statistical methods as well as machine learning approaches were explored, and a cohesive hierarchical clustering algorithm will be used. After developing the model, a symptom-matched intervention program based on problem solving therapy will be formulated. We are supposed to examine whether its use for personalizing symptom-matched psychological treatment can lead to improved patient outcomes, compared with usual care. This project is expected to provide a new and precise method for the emotion management, which will provide a standardized intervention pathway combining screening with treatment for the management of depression symptom and anxiety symptom. A preciser intervention matched to individual symptoms may provide important insight in improving patient outcome as well as a standardized mood management pathway targeting to the early detection and intervention for community residents.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 8 weeks Problem-solving therapy | Experimental | Problem-solving therapy imparts problem-solving abilities applicable to participants' daily lives. Personalized therapies, including brief behavioral treatment of insomnia, mindfulness, and physical exercise suggestions, were tailored to correspond with patients' specific clusters of sadness and anxiety symptoms. |
|
| treatment as usual | Placebo Comparator | Care as usual with the PST-PC learning manual and health education information. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| problem solving therapy | Behavioral | Problem-solving therapy-based holistic emotion management interventions matched to individual symptoms |
|
| Measure | Description | Time Frame |
|---|---|---|
| The Patient Health Questionnaire (PHQ-9) | Baseline, week 1, week 2, week 3, week 4, week 5, week 6, week 7, week 8, week 12, week 20, week 32 | |
| GAD-7 | Baseline, week 1, week 2, week 3, week 4, week 5, week 6, week 7, week 8, week 12, week 20, week 32 |
| Measure | Description | Time Frame |
|---|---|---|
| PSQI | Baseline, week 1, week 4, week 6, week 8, week 12, week 20, week 32 | |
| WHODAS 2.0 | Baseline, week 1, week 4, week 6, week 8, week 12, week 20, week 32 | |
| EQ-5D-5L |
| Measure | Description | Time Frame |
|---|---|---|
| remission rate | PHQ-9 < 5 AND/OR GAD-7 < 5 | week 8, week 12, week 20, week 32 |
| SBQ-R | It was utilized to assess suicide ideation for exclusion |
Inclusion Criteria:
Exclusion Criteria:
People will be excluded if they meet any of the following criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Renmin Hospital of Wuhan University | Recruiting | Wuhan | China |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| control group | Other | Routine psychological care and guidance on mood management |
|
| Baseline, week 1, week 4, week 6, week 8, week 12, week 20, week 32 |
| week -1 pre-screening |
| D008722 | Methods |