Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

Predictive Value of Serum Uric Acid to High Density Lipoprotein Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes

Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.

Inclusion Criteria:

• Type 2 diabetic patients
• willing and agreed to be included in the study

Exclusion Criteria:

• Type 1 DM patients
• patients with active urinary sediment
• patients with glomerulonephritis
• patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease
• patients with evidence of alternative kidney disease
• patients with history of kidney transplantation
• patients with end stage renal disease
• patients with family history of non diabetic forms of kidney disease
• patients with active malignancy
• patients with established hemolytic disease
• CKD patients requiring dialysis
• patients taking drugs that interfere with serum uric acid level
• patients taking drugs that alter serum lipids level
• pregnancy
• Refused to consent to this study