An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes

Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.

Inclusion Criteria:

• Type 2 diabetic patients
• willing and agreed to be included in the study

Exclusion Criteria:

• Type 1 DM patients
• patients with active urinary sediment
• patients with glomerulonephritis
• patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease
• patients with evidence of alternative kidney disease
• patients with history of kidney transplantation
• patients with end stage renal disease
• patients with family history of non diabetic forms of kidney disease
• patients with active malignancy
• patients with established hemolytic disease
• CKD patients requiring dialysis
• patients taking drugs that interfere with serum uric acid level
• patients taking drugs that alter serum lipids level
• pregnancy
• Refused to consent to this study

we will prospectively enroll patients from internal medicine department from march 2024 to august 2024 .all patients will be subjected to

1. Detailed medical history including : demographic characteristics,comorbid conditions,duration of diabetes mellitus,type of treatment and diabetic complications
2. Detailed clinical examination including : height , weight ,waist circumferenc,SBP,DBP,BMI
3. Fundus examination for retinopathy