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| Name | Class |
|---|---|
| Henan Provincial Chest Hospital | OTHER |
| The Affiliated Infectious Disease Hospital of Zhengzhou University | UNKNOWN |
| The Fifth People's Hospital of Anyang | UNKNOWN |
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To establish a real-world clinical cohort and database of Azvudine in the treatment of SARS-CoV-2 infection, and to provide stable and reliable evidence for the clinical efficacy and safety evaluation of azvudine in the treatment of SARS-CoV-2 infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Azvudine | COVID-19 patients with Azvudine treatment |
| |
| Paxlovid | COVID-19 patients with Paxlovid treatment |
| |
| Control | COVID-19 Patients who have not been treated with Azvudine or Paxlovid |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Azvudine | Drug | Antiviral drug |
| |
| Paxlovid |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause death | All-cause death was ascertained by electronic medical records. | Up to 30 days (form the date of confirmed COVID-19) |
| Measure | Description | Time Frame |
|---|---|---|
| Composite disease progression | Disease progression is defined as the occurrence of death, progression to severe or critical disease in mild or moderate patients, and the occurrence of death, progression to critical disease in severe patients. Severe disease is defined as respiratory rate ≥ 30 times/minute, or resting oxygen saturation ≤ 93%, or PaO2/FiO2 ≤ 300 mmHg, or lung lesions progressing >50% at 24-48 hours. Critical disease is defined as the need for mechanical ventilation, or shock, or ICU monitoring. |
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Inclusion Criteria:
Exclusion Criteria:
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People who have COVID-19 and have an indication for Azvudine or Paxlovid.
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| Name | Affiliation | Role |
|---|---|---|
| Zujiang Yu, Dr. | The First Affiliated Hospital of Zhengzhou University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou | Henan | 450052 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40578868 | Derived | Wang F, Jia B, Li G, Jin X, Yang M, Li G, Zhang S, Qian G, Luo H, Cheng M, Wang L, Zhang D, Li S, Liang H, Ren Z. Real-world effectiveness and safety of oral azvudine versus Paxlovid in patients with COVID-19 and pre-existing hypertension: a multicentre, retrospective, cohort study in Henan Province, China. BMJ Open. 2025 Jun 27;15(6):e090230. doi: 10.1136/bmjopen-2024-090230. | |
| 40389963 |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| C540945 | azvudine |
| C000719967 | nirmatrelvir and ritonavir drug combination |
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| Shangqiu Municipal Hospital |
| UNKNOWN |
| Nanyang Central Hospital | OTHER |
| Luoyang Central Hospital | OTHER |
| Guangshan County People's Hospital | UNKNOWN |
| Fengqiu County People's Hospital | UNKNOWN |
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| Drug |
Antiviral drug |
|
|
| Up to 30 days (form the date of confirmed COVID-19) |
| Derived |
| Su G, Gao F, Yang M, Wang L, Liang L, Li S, Li G, Han N, Li G, Qian G, Zhang S, Luo H, Zhang D, Liang H, Ren Z. Effectiveness of azvudine versus nirmatrelvir/ritonavir for hospitalized patients with SARS-CoV-2 infection and pre-existing liver diseases. Virol J. 2025 May 19;22(1):147. doi: 10.1186/s12985-025-02771-1. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |