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The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cTBS to Ventrolateral Prefrontal Cortex | Experimental | Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the ventrolateral prefrontal cortex. |
|
| cTBS to Dorsomedial Prefrontal Cortex | Experimental | Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the dorsomedial prefrontal cortex. |
|
| cTBS to Vertex | Experimental | Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the vertex. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Repetitive Transcranial Magnetic Stimulation (rTMS) | Device | Continuous theta burst rTMS |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acute effects of cTBS on cognitive control | between-arm differences in neurocognitive task performance as measured by percent correct on an inhibitory control task and self reported craving on a regulation of craving task. | 1 hour after receiving cTBS |
| Measure | Description | Time Frame |
|---|---|---|
| Exploratory: Acute effects of cTBS on fMRI brain response | between-arm differences in whole brain fMRI BOLD functional connectivity. Neural network connectivity will be characterized using rZ values. | 1 hour after receiving cTBS |
| Measure | Description | Time Frame |
|---|---|---|
| Safety and Tolerability | Safety and tolerability of cTBS administered to each cortical location, as measured by self reported side effects on a review of symptoms questionnaire. | 24 hours following receipt of cTBS |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Brett Froeliger, PhD | Contact | 573-882-4785 | froeligerb@health.missouri.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Health Neuroscience Center | Recruiting | Columbia | Missouri | 65203 | United States |
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| ID | Term |
|---|---|
| D014029 | Tobacco Use Disorder |
| D012907 | Smoking |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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