92 patients with a diagnosis of primary knee pain of unknown cause followed at the family medicine outpatient clinic and who met our exclusion criteria were invited to the study. When creating patient list, the examination of patients, interviews with patients, as well as their medical records and examinations were used. Patients were divided into two groups: prolotherapy (n=46) and control group (n=46) by simple randomization method. However, when the study started, 32 people in the prolotherapy group and 33 people in the control group of these patients participated in the study. Prior to the research, detailed information was provided about the research in the experimental and control groups and signed consent was obtained from all participants that they volunteered to participate in the research. 5% dectrose was applied to the prolotherapy group by injection method to the pain area. In the control group, existing medical treatments were continued and no injection procedure was performed. Before the research, all participants were evaluated with Case Report Form, Visual Analog Scale (VAS) and Quality of Life Scale Short Form (SF-36). The cases in the experimental and control groups were re-evaluated with the VAS and SF-36 scales at the first month.

Inclusion Criteria:

• patients who suffer from primary knee osteoarthritis

Exclusion Criteria:

• Inflammatory knee pain
• Cellulitis
• Septic arthritis
• Local abscess
• Bleeding disorders
• Patient on anticoagulant medication
• Patients allergic to dextrose
• Diabetes Mellitus
• breathing problems
• Electrolyte imbalance
• Kidney or liver disease

Data will be shared on demand. Sharing data identifying patients is forbidden in Türkiye.