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Randomized clinical trial between 2groups,the study group to be injected in the TMJ with injectable platelet rich fibrin with vitamin C and the control group to be injected in the TMJ with injectable platelet rich fibrin alone in management of internal Temporomandibular joint derangement
Randomized clinical trial between 2groups,the study group to be injected in the TMJ with injectable platelet rich fibrin with vitamin C and the control group to be injected in the TMJ with injectable platelet rich fibrin alone in management of internal Temporomandibular joint derangement
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intervention group | Experimental | injection of injectable platelet rich fibrin with vitamin C |
|
| control group | Active Comparator | injection of injectable platelet rich fibrin alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin C | Drug | addition of vitamin C to IPRF |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain management | Evaluation of pain using VAS pre and post injections | at 4;8;12;16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| disc position using MRI | evaluation of disc position pre and post injections | at 4;8;12;16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| maximum mouth opening | measurement of MMO using digital caliper pre and post injections | at 4;8;12;16 weeks |
| lateral excursion | measurement of lateral excursion using digital caliper pre and post injections |
Inclusion Criteria:
Patients with internal TMJ derangement (anterior disc displacement with reduction)
Exclusion Criteria:
Pathological conditions ; trauma TMJ cases or any blood diseases
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry cairo university | Cairo | +2 | Egypt |
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| ID | Term |
|---|---|
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Injectable platelet rich fibrin | Other | injection of IPRF alone |
|
|
| at 4;8;12;16 weeks |
| D006880 |
| Hydroxy Acids |
| D002241 | Carbohydrates |