Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing

Comparison of the Effects of Different Natural and Synthetic Intracanal Medicaments on the Healing of Periapical Lesion in Retreatment Cases (A Randomized Clinical Trial)

The goal of this clinical trial is to compare the effects of different intracanal medication between endodontic retreatment visits in previously failed root canal treatment patients (single root canal anteriors or premolars teeth). The main question it aims to answer are:

• Is natural and synthetic intracanal Medicament effective in reducing or complete healing of Periapical lesions or not? the researchers will compare the effect of different intracanal dressing including:
• nanocurcumin gel
• curcumin gel
• ciprofloxacin +ibuprofen gel
• calcium hydroxide Paste as control group in between the endodontic retreatment visits to see if these medicaments work well on periapical lesion healing this outcome measured by Cone beam CT at base and after 1 year follow up period

Inclusion Criteria:

• Medically free Patients
• both sex includes male and females
• Patients age between 20-60
• Patients agreement positively to share in the study
• patient able to sign informed consent
• on clinical and radiographic examinations, the included teeth maxillary and mandibular single root canal anteriors or premolars suffering from failed endodontic treatment with periapical lesion

Exclusion Criteria:

• badly broken down teeth indicated for extraction or with difficult isolation
• teeth with former procedural errors as ledge, perforation or instrument separation
• Medically compromised patients
• patients with history of receiving antibiotics within a month before starting study
• periodontally affected teeth by pocket depth & > 4mm