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| ID | Type | Description | Link |
|---|---|---|---|
| A539500 | Other Identifier | UW- Madison | |
| SMPH/SLEEP CENTER/SLEEP CTR | Other Identifier | UW- Madison | |
| Protocol Approved 8/6/2024 | Other Identifier | UW- Madison | |
| 1R01MH132221 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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The goal of this clinical trial is to characterize the role of sleep, emotion processing, and daily affect in post-traumatic stress disorder (PTSD) and whether improving sleep quality using slow wave activity enhancement will impact next-day affect in youth.
Participants will attend 4 study visits:
In this study, researchers aim to characterize sleep and explore its relationship to emotion processing and daily affect in 165 youth spilt into 3 groups. Researchers will use advanced sleep assessment methodologies including: (1) high-density EEG (256 channels) in the laboratory to explore the regional distribution of sleep before and after an emotional learning task and; (2) a sleep-wearable EEG recording headband, SmartSleep, to record sleep longitudinally at home. Using SmartSleep's sleep enhancement algorithms, researchers will determine whether the deepest sleep, slow-wave activity (SWA) of non-rapid eye-movement (NREM) sleep, can be reliably increased in all youth.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stimulation mode first | Experimental | During one week, the SmartSleep device will be set to stimulation mode. |
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| Sham mode first | Sham Comparator | During one week, the SmartSleep device will be set to sham. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SmartSleep device | Device | Device worn during sleep |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Emotional Regulation - arousal | Participants will view 140 target stimuli - 70 negative and 70 neutral- in pseudorandom order. The Self-Assessment Manikin Scale for Arousal 142 (SAM) appears after the target image and participants are asked to rate degree of emotional arousal experienced while processing the picture by pressing one of nine response buttons (ranging from 1 = very low to 9 = very high). | First overnight session to second overnight, up to 5 weeks |
| Change in Emotional Regulation - recall | Participants complete a recognition phase. In this phase, 200 neutral and negative images are viewed. This set includes the 140 previously viewed images intermixed with 70 novel images (50% negative and 50% neutral). Participants are asked to assess arousal using the SAM (degree of emotional arousal experienced while processing the picture by pressing one of nine response buttons (ranging from 1 = very low to 9 = very high)), and to indicate whether or not they recognize pictures from the previous encoding session (''old'') or not (''new'') by pressing one of two response buttons. | First overnight session to second overnight, up to 5 weeks |
| Change in Slow-wave Activity (SWA) | Measured by overnight high-density EEG | First overnight session to second overnight, up to 5 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Positive and Negative Affect Schedule (PANAS) | PANAS consists of 10 positive and 10 negative valence word items. Items are rated by the participant to indicate their assessment of how they are feeling about this item "right now" on a scale of 1(slightly) or not at all through 5 (extremely). 10 of of the items form a positive affect subscale, in which a higher score indicates increased positive affect, with a subscale range of 10 to 50. 10 of the items form a negative affect subscale, in which a higher score indicates more negative affect, with a subscale range of 10 to 50. |
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Inclusion Criteria:
All participants must meet all of the following criteria:
In addition, PTSD and TEC youth must satisfy the following criteria:
- Must have a history of at least one traumatic event of any type, as defined by the DSM-V. This may include exposure to physical or sexual abuse, witnessing violence against loved ones or friends, traumatic accidents, natural disasters, death of a close family member etc.
Additional criteria for PTSD youth:
- At baseline, meet threshold for DSM-5 criteria for current severe PTSD, as determined by the semi-structured clinical interview (KSADS).
Exclusion Criteria:
Exclusions for Typically developing youth:
PTSD Youth:
- Current diagnosis of or history of psychotic disorder, bipolar disorder, or autism spectrum disorder diagnosed by the KSADS interview. No other co-morbid disorders are exclusionary.
TEC Youth:
- A current diagnosis of PTSD or a current diagnosis of or history of psychotic disorder, bipolar disorder, or autism spectrum disorder diagnosed by the KSADS interview.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sara Heyn, JD, PhD | Contact | 303-296-2116 | sheyn@wisc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Stephanie Jones, MD, PhD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin | Recruiting | Madison | Wisconsin | 53705 | United States |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| First week at-home recordings to second week, up to 6 weeks |