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This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.
Acute kidney injury (AKI) after liver transplantation (LT) significantly affects patient and graft outcomes. The Albumin-Bilirubin (ALBI) score, an objective and sensitive index of liver function, has potential applicability in predicting outcomes following LT. This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Recipients with neohepatic ALBI ≥ -1.615 | The ALBI score was calculated using the formula: (log10bilirubin × 0.66) + (albumin × -0.085), where bilirubin is measured in μmol/L and albumin in g/L. Recipients with neohepatic (post-reperfusion) ALBI ≥ -1.615 | ||
| Recipients with neohepatic ALBI < -1.615 | Recipients with neohepatic (post-reperfusion) ALBI < -1.615 |
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| Measure | Description | Time Frame |
|---|---|---|
| acute kidney injury | determined by change in sCr according to the Kidney Disease: Improving Global Outcomes (KDIGO) definition (increase in sCr of ≥26.5 mmol litre-1 within 48h or ≥1.5 times baseline within 7 days after surgery | within 7 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| chronic kidney injury | when renal function assessed by calculating estimated serum glomerular filtration using the abbreviated modification of diet in renal disease equation was <60 mL/min/1.73 m2 for 3 months or more, irrespective of cause | within 1 year after surgery |
| graft failure |
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Inclusion Criteria:
Exclusion Criteria:
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living donor liver transplantation recipients at Asan Medical Center, Seoul, Korea from January 2012 to December 2019
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan Medical Center | Seoul | Song-pa Gu | 05500 | South Korea |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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graft failure |
| the graft failure at overall period (calculated from the date of surgery to the last follow-up) from the date of surgery (up to 10 years)] |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |