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For the management of low-density lipoprotein-cholesterol (LDL-C), some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in LDL-C levels. High-intensity or maximally tolerated intensity can be maintained without a target goal. However, the European guideline recommends less than 55 mg/dL of LDL-C after PCI.
To investigate the Optimal Attained LDL-C Levels in Patients Who Achieved ≥50% LDL-C Reduction After PCI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| >=50% LDL-C reduction | LDL-C reduction >=50% Further divided by LDL <55mg/dL 55< LDL < 70 mg/dL LDL > 70 mg/dL |
| |
| <50% LDL-C reduction | LDL-C reduction <50% |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LDL reduction therapy | Drug | LDL reduction therapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| MACCE | major adverse cardiac and cerebrovascular events | 10 years after PCI |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular death | death from cardiovascular cause | 10 years after PCI |
| Spontaneous myocardial infarction | MI with hospitalziation |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with coronary artery disease undergoing PCI
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40294950 | Derived | Kang D, Choi KH, Yang S, Kim H, Park TK, Lee JM, Cho J, Yang JH, Song YB, Choi SH, Gwon HC, Hahn JY. Clinical significance of low-density lipoprotein cholesterol percentage reduction and attained levels after percutaneous coronary intervention. CMAJ. 2025 Apr 27;197(16):E442-E452. doi: 10.1503/cmaj.241713. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 10 years after PCI |
| Repeat revascularization | additional PCI or CABG | 10 years after PCI |
| Ischemic stroke | Stoke from ischemic cause | 10 years after PCI |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |