The Impact of Different Exercise Modes on Bile Acid Levels and Liver Function in Patients With Non-alcoholic Fatty Liver Disease

The Impact of Different Exercise Modes on Bile Acid Levels and Liver Function in Patients With Non-alcoholic Fatty Liver Disease

The purpose of this clinical trial is to investigate which exercise regimen is more effective in improving non-alcoholic fatty liver disease (NAFLD) in a young population. The primary questions it aims to answer are:

Does aerobic training, resistance training, or a combination of both help improve liver function and glycemic and lipid parameters in NAFLD patients? Which of these three exercise regimens is more effective in improving the aforementioned parameters? Is the improvement in liver function related to bile acid metabolism?

Participants will:

Engage in physical exercise 4-5 times per week for two consecutive months, following a predefined exercise regimen.

Have blood samples collected to test for glucose, lipids, liver function, and other parameters before starting the exercise program and after two months of completing the regimen.

Inclusion Criteria:

• Body fat percentage >20% or BMI >24
• The diagnostic result of abdominal ultrasonography is fatty liver
• No regular exercise under guidance in the past 3 months
• No medication taken in the last month
• No binge eating or heavy drinking in the past two weeks

Exclusion Criteria:

• Long history of alcohol consumption, equivalent to more than 30g/day of ethanol
• Viral hepatitis
• History of autoimmune or genetic diseases
• History of drug-induced liver disease
• History of total parenteral nutrition
• History of cardiovascular, respiratory, or other diseases that necessitate avoidance of intense physical activity.