The aim of this observational study is to assess the effectiveness of automatic insulin infusion in responding to changes in insulin sensitivity throughout various phases of the menstrual cycle in a cohort of reproductive-aged women with type 1 diabetes, using an advanced closed-loop system. By gaining insights into both the limitations and effectiveness of this adaptation, we aim to inform the enhancement of control algorithms and learning strategies within closed-loop systems. This research is especially vital for addressing the distinct challenges that women commonly encounter in maintaining glycemic control.

Inclusion Criteria:

• Diagnostic criteria for DM1 according to ADA
• Women and men treated with the Medtronic© MinimedTM 780G advanced closed loop system.
• Women presenting spontaneous regular menstrual cycles with a duration of 24 to 35 days, during the last year.
• Men under 50 years old.
• Acceptance of participation in the study and signing of the informed consent

Exclusion Criteria:

• Gestation
• Use of hormonal contraceptives (including intrauterine devices)
• Institutionalization, serious or terminal illness or renal replacement therapy.
• Refusal to participate in the study or to sign the informed consent

Sixty-nine women of reproductive age will be recluted to investigate fluctuations in glycemic control throughout the menstrual cycle. Furthermore, a subgroup comprising 50 of these women, along with a control group consisting of 50 men, will wear a wearable device to gather temperature, photoplethysmography, and accelerometry data

Patients of both genders, aged 18 or older, with type 1 diabetes and in their reproductive years, receiving care at the Endocrinology and Nutrition Department of Ramón y Cajal University Hospital in Madrid, and undergoing treatment with the Medtronic© MinimedTM 780G closed loop advanced system.