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There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound.
Carotid web are rare, focal dysplasia of the internal carotid artery and a high risk causes of stroke in young adult. Natural history of these dysplasia remains poorly understood. High prevalence of carotid web among Afro-Caribbean population and the similarity between carotid web and fibromuscular dysplasia, suggest existence of genetic factors. But there has been to our knowledge no familial form of carotid web reported. The aim of this study is to determine the prevalence of carotid web among relatives of patients with carotid web using carotid duplex doppler ultrasound.
Researchers aim to test whether carotid web could be detected in relatives of patients with known carotid web, using duplex doppler ultrasound.
This is a pilot, transversal, single-center study performed at Toulouse University Hospital, France. From 30 carotid web cases aged under 65 (patients with previously known Carotid web, symptomatic or not) followed in neurology department, investigators aim to include 60 first-degree relatives younger than 65 years old. Included relatives will underwent carotid duplex doppler ultrasound to detect carotid web. The primary outcome is the prevalence of carotid web among relatives. Secondary outcomes include : Number of families with at least one relative who has been diagnosed with carotid web, number of relatives who has been diagnosed with carotid web per family, clinical characteristics of patients and morphological characteristics of carotid web.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Doppler ultrasound | Experimental | First degree relatives of patient with diagnosed carotid web will receive an echography doppler of the carotid arteries and answer questionnaires |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Doppler ultrasound | Procedure | Participants will receive doppler ultrasound of the carotid arteries, and no other interventions studied |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the prevalence of carotid web by doppler ultrasound in first-degree relatives of patients with carotid web. | Number of first-degree relatives with at least one carotid web on doppler ultrasound. | Inclusion day |
| Measure | Description | Time Frame |
|---|---|---|
| Description of the clinical characteristics of relatives with carotid web and their index case. | Clinical characteristics of relatives with a carotid web and index cases: age, sex, vascular risk factors, medical history, family history, current treatments, bilateral nature of the carotid web. | Inclusion day |
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Inclusion Criteria:
Carotid Web index patients:
Relatives patients :
- First degree relatives of patient with diagnosed carotid web.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Louis FONTAINE, MD | Contact | 05 61 77 93 67 | +33 | fontaine.l@chu-toulouse.fr |
| Name | Affiliation | Role |
|---|---|---|
| Claire VILLEPINTE, MD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Toulouse, Purpan | Recruiting | Toulouse | 31059 | France |
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| Description of the morphological characteristics of relatives with carotid web and their index case. |
Morphological characteristics on doppler ultrasound of the carotid web in relatives and in index cases: length, width, echogenicity, hemodynamic impact. |
| Inclusion day |